Likely to advise antibiotics, IVF and laboratory investigations rationally compared to their non-qualified counterparts. Intuitively enough this observation supported previous findings and established the need for urgent interventions to bring non-qualified practitioners under the coverage of regular training schedule and monitoring to improve CCX282-B cancer overall management of diarrhea in settings where nonqualified practitioners would remain an integral part of healthcare [40, 42, 49]. Longer duration of practice was associated with higher odds of order ABT-737 rational antibiotic use in case of watery/bloody diarrhea. An exploratory research involving physicians in peri-urban area of Lima, Peru previously illustrated that length of practice was an important predictor ofPLOS ONE | DOI:10.1371/journal.pone.0123479 April 7,9 /Rational Management of Diarrheaappropriate prescription habit among practitioners [53] while some other studies also reported similar influence of practitioners’ experience on management practices [3, 40, 50]. Practitioners attached to Government hospitals had much higher likelihood of rational antibiotic use, fluid management and laboratory investigations while treating diarrhea cases compared to those who were only doing independent practices and for practitioners working in private sector the scenario in terms of rationality also seemed to be better than those practitioners without attachments. These findings corroborated with previous studies where public sector physicians were found to be more likely to prescribe antibiotics rationally than others [6, 12, 40, 42, 43]. Practitioners’ domain-wise and overall knowledge regarding diarrheal diseases, their prevention/control and management seemed to be major drivers of their rational diarrhea management practices. Better knowledge about diarrheal management and cholera was significantly associated with rational antibiotic use in acute watery/bloody diarrhea. Knowledge regarding ORS was positively correlated with the likelihood of better antibiotic treatment of mucoid diarrhea. Those having best knowledge about signs, symptoms, occurrence and spread of diarrhea had higher odds of prescribing antibiotics rationally in any type of diarrheas compared to their less knowledgeable counterparts. Although similar observation was reported from several studies in comparable settings [15, 40, 44, 51?3], lack of association between knowledge and rationality were also observed among practitioners regarding antibiotic use [38, 43, 47]. Factors like patient/caregivers’ preferences, affordability and severity of diarrhea were other strong predictors [38, 40, 46, 47, 50, 54?6]. Rational fluid therapy was significantly predicted by best knowledge regarding diarrheal signs/symptoms, occurrence/spread, prevention/control and ORS. Physicians’ knowledge and other patient related factors were found to have strong correlations in other studies also [3, 32, 57]. Corroborating with prior explorations, it was found in our study that, relatively improved knowledge about diarrheal management, prevention/control and cholera was associated with higher odds of rational laboratory testing advice and strategy. [52, 58] Practitioners having better overall knowledge regarding diarrhea were much more likely to prescribe rational antibiotics, administer appropriate IVF to correct severe dehydration and advise laboratory investigations rationally while managing diarrhea cases. Improvement of overall diarrheal management was also e.Likely to advise antibiotics, IVF and laboratory investigations rationally compared to their non-qualified counterparts. Intuitively enough this observation supported previous findings and established the need for urgent interventions to bring non-qualified practitioners under the coverage of regular training schedule and monitoring to improve overall management of diarrhea in settings where nonqualified practitioners would remain an integral part of healthcare [40, 42, 49]. Longer duration of practice was associated with higher odds of rational antibiotic use in case of watery/bloody diarrhea. An exploratory research involving physicians in peri-urban area of Lima, Peru previously illustrated that length of practice was an important predictor ofPLOS ONE | DOI:10.1371/journal.pone.0123479 April 7,9 /Rational Management of Diarrheaappropriate prescription habit among practitioners [53] while some other studies also reported similar influence of practitioners’ experience on management practices [3, 40, 50]. Practitioners attached to Government hospitals had much higher likelihood of rational antibiotic use, fluid management and laboratory investigations while treating diarrhea cases compared to those who were only doing independent practices and for practitioners working in private sector the scenario in terms of rationality also seemed to be better than those practitioners without attachments. These findings corroborated with previous studies where public sector physicians were found to be more likely to prescribe antibiotics rationally than others [6, 12, 40, 42, 43]. Practitioners’ domain-wise and overall knowledge regarding diarrheal diseases, their prevention/control and management seemed to be major drivers of their rational diarrhea management practices. Better knowledge about diarrheal management and cholera was significantly associated with rational antibiotic use in acute watery/bloody diarrhea. Knowledge regarding ORS was positively correlated with the likelihood of better antibiotic treatment of mucoid diarrhea. Those having best knowledge about signs, symptoms, occurrence and spread of diarrhea had higher odds of prescribing antibiotics rationally in any type of diarrheas compared to their less knowledgeable counterparts. Although similar observation was reported from several studies in comparable settings [15, 40, 44, 51?3], lack of association between knowledge and rationality were also observed among practitioners regarding antibiotic use [38, 43, 47]. Factors like patient/caregivers’ preferences, affordability and severity of diarrhea were other strong predictors [38, 40, 46, 47, 50, 54?6]. Rational fluid therapy was significantly predicted by best knowledge regarding diarrheal signs/symptoms, occurrence/spread, prevention/control and ORS. Physicians’ knowledge and other patient related factors were found to have strong correlations in other studies also [3, 32, 57]. Corroborating with prior explorations, it was found in our study that, relatively improved knowledge about diarrheal management, prevention/control and cholera was associated with higher odds of rational laboratory testing advice and strategy. [52, 58] Practitioners having better overall knowledge regarding diarrhea were much more likely to prescribe rational antibiotics, administer appropriate IVF to correct severe dehydration and advise laboratory investigations rationally while managing diarrhea cases. Improvement of overall diarrheal management was also e.