Nificant effect on the level of glucose-6-phosphatase and fructose-1,6 biphosphatase,which decreased to considerable level in dose dependent manner. Maximum effect was observed in 400 mg/kg body weight. The reduction in the above two biochemical enzymes portrays the sequential metabolic correlation between increased glycolysis and decreased glyconeogenesis. In the pathogenesis of diabetes, lipid plays a significant factor. Increased level of cholesterol and lipids in plasma represent a risk factor for coronary artery disease [60]. Increased level of total cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-cholesterol), very low density lipoprotein cholesterol (VLDL-cholesterol) was observed in streptozotocin induced diabetic rats. Hypercholesterolemia in the rats received streptozotocin is caused by increased intestinal absorption and increased cholesterol biosynthesis [54]. Treatment with ALEx reduced PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/26024392 the total cholesterol, LDL-c, VLDL-c and triglycerides level to a significant extent in dose dependent manner, while increasing the beneficial HDL level to a considerable extent. It is assumed that ALEx may exert its hypocholesterolemic effect either due to decreased intestinal absorption or decreased cholesterol biosynthesis. The lipoproteins in the diabetic rats are oxidized and may be cytotoxic, which can be reversed by the administration ofAhmed et al. BMC Complementary and Alternative Medicine 2014, 14:243 http://www.biomedcentral.com/1472-6882/14/Page 15 ofFigure 12 Effect of Albizia Lebbeck Benth. stem bark extract (ALEx) on histological profile of heart in normal, STZ-induced diabetic untreated and STZ-induced diabetic treated wistar rats (Original magnification 40? DXIT 1200 , Nikon, Japan). (i) NHALx: Heamatoxylin and eosin (H/E) stained sections of heart (oblique cut) of normal control rats showing well arranged cardiac myocytes and normal striations (yellow arrows). (ii) STZH: Section of heart of STZ-induced diabetic rats depicting disarranged cardiac myocytes with destroyed striations (yellow arrows). (iii) ALEx100: Cardiac section of rats received 100 mg/kg body wt. of ALEx portraying better striations (yellow arrows). (iv) ALEx200: Heart section of diabetic rats administered with 200 mg/kg body wt. of ALEx showing improved arrangement of cardiac myocytes (yellow arrows). (v) ALEx 300: Section of heart of diabetic rats supplemented with 300 mg/kg body wt. of ALEx, showing nearly normal cardiac myocytes and striations (yellow arrows). (vi) ALEx400: H/E stained section of heart of diabetic rats received 400 mg/kg body wt. of ALEx depicting normal arrangement of cardiac myocytes and normal striations (yellow arrows). HGLB: Heart section of diabetic rats administered with Glibenclamide portraying normal cardiac myocytes (yellow arrows).antioxidants [61]. Our results clearly demonstrated that ALEx recovered the imbalanced lipid profile of STZ induced diabetic rats in dose dependent manner. Antioxidant capacity is reduced to a significant extent in the plasma of STZ-induced diabetic rats, due to the higher requirement of antioxidants in order to BMS-791325MedChemExpress Beclabuvir regulate the reactive oxygen species (ROS) homeostasis [62]. Nevertheless, enhanced plasma antioxidant capacity in conjunction with reduced lipid peroxidation could be attained by regular ingestion of rich source of antioxidant compounds. In our research exertion, we examined the antioxidant capacity of ALEx. ROS can be primarily eliminated by essential free radical scave.