OfTable two. Cont.Study Study Area Study C2 Ceramide Activator period Threshold Temperature 1 Hot Weather Description 2 Outcomes three T as predictor for the mortality from CHD (304 years old) RR = 1.19 (95 CI: 0.09.21); PET for mortality from CVD (304) = 1.64 (95 CI: 0.18.43), 2 day lag; PET as predictor (elderly): CHD = 1.51 (95 CI: 0.09.03) 3 day lag, CVD = 1.72 (95 CI: 0.058.63), 1 day lag Increase in mortality using: maximum everyday T for females all-cause (304) = 1.80; RD (elderly) = 0.66; maximum UTCI for guys with CVD (304) = 0.67, (elderly) = 2.83 Enhance in hypertensive crises, unscheduled visits for the medical professional, cardiac arrhythmiasShartova et al. [110]Rostov n on1999011 (excluding 2010)Daily T, HUM, AT, PETHW: T (HUM, AT, PET) 97th percentile of the year-round distribution through the study period, Glycodeoxycholic Acid Epigenetics duration 5 daysShartova et al [111]Arkhangelsk1999Daily T, UTCIHW: T (UTCI) 97th percentile with the year-round distribution throughout the study period, duration 5 daysSmirnova et al. [115]MoscowSummerDaily T Cold WavesHWAgeev [43]Moscow2012Daily TCW: T 3rd percentile of your year-round distribution through the study period, duration 5 days CW: T 3rd percentile of your year-round distribution during the study period, duration 5 days CW: T 3rd percentile from the year-round distribution through the study period, duration 5 days CW: T (WCI) 3rd percentile on the year-round distribution throughout the study period, duration 5 days CW: T (WCI) 3rd percentile from the year-round distribution throughout the study period, duration 5 daysIncrease in cardiovascular exacerbations in some individuals with CVD: hypertensive crisis, ambulance calls Absolute risk of mortality boost: for CVD (elderly) = four.81 10-3 ; ED (304 years old) = 1.45 10-Chernykh, Taseiko [55]Krasnoyarsk2000004, 2010Daily TRevich [94]Moscow2000Daily T65 years old: IHD = 1.05 (95 CI: 1.03.07), CVD = 1.08 (95 CI: 1.05.10), NA = 1.05 (95 CI: 1.04.06)IHD (304 years old) RR = 1.30 (95 CI: 1.12.51), RD (304) = 1.39 (95 CI: 1.03.87), ED (304) = 1.27 (95 CI: 1.04.54). No important results for the elderly Raise in all-cause mortality (304 years old) RR = 7.3 (95 , CI: 1.13.8), (elderly) = 6.3 (95 , CI: 1.71.2) Boost in mortality, T as predictor: Arkhangelsk, IHD RR = 1.16 (95 CI: 1.037.31), CVD = 1.30 (95 CI: 1.15.46) Murmansk IHD = 1.24 (95 CI: 1.07.42), CVD = 1.10 (95 CI: 0.94.29) Yakutsk IHD = 1.26 (95 CI: 1.03.53), CVD = 1.36 (95 CI: 1.05.76) T as predictor: RD (65) RR = 1.19 (95 CI: 1.01.40)Revich [94]Vladivostok2000Daily TRevich, Shaposhnikov [98]Krasnoyarsk1999Daily T, WCIRevich et al. [99]Northern cities Arkhangelsk, Murmansk, Yakutsk1999Daily T, WCICW: T (WCI) 3rd percentile on the year-round distribution through the study period, duration 5 daysRevich et al. [101]St-Petersburg1999Daily T, WCICW: T (WCI) 3rd percentile in the year-round distribution throughout period from 1961 to 2017, duration five daysShaposhnikov, Revich [107]Northern cities Arkhangelsk, Magadan, Murmansk, Yakutsk1999Daily TCW: T (WCI) 3rd percentile of the year-round distribution through study period, duration 5 daysArkhangelsk: IHD (304 years) RR = 1.18, (65) = 1.22; CVD (304) = 1.13, (65) = 1.19; RD (304 years) = 1.31; NA (304) = 1.12, NA (65) = 1.18; Murmansk: IHD (304) = 1.18; Magadan: IHD (65) = 1.39; CVD (65) = 1.66; Yakutsk: IHD (304) = 1.38, (65) = 1.41; CVD (65) = 1.69; RD (65) = 1.97, NA (65) = 1.24 Boost in mortality: mean every day T for females (304 years old) CHD = 0.74, RD (65) = 0.58; minimum each day U.