Pplicable. Acknowledgments: We thank Episil Holding Inc., Taiwan, for device fabrication.
Pplicable. Acknowledgments: We thank Episil Holding Inc., Taiwan, for device fabrication. Conflicts of Interest: The authors declare no conflict of interests.
brain sciencesArticleDiffusion Tensor Imaging Modifications Usually do not Affect Long-Term Neurodevelopment following Early Erythropoietin among Particularly Preterm Infants within the Preterm Erythropoietin Neuroprotection TrialJanessa B. Law 1, , Bryan A. Comstock 2 , Todd L. Richards three , Christopher M. Traudt 1 , Thomas R. Wood 1 , Dennis E. Mayock 1 , Patrick J. Heagerty 2 , Charybdotoxin web Sandra E. Juul 1 and on behalf in the PENUT Trial ConsortiumDivision of Neonatology, Division of Pediatrics, University of Washington, Seattle, WA 98195, USA; [email protected] (C.M.T.); [email protected] (T.R.W.); [email protected] (D.E.M.); [email protected] (S.E.J.) Division of Biostatistics, University of Washington, Seattle, WA 98195, USA; [email protected] (B.A.C.); [email protected] (P.J.H.) Department of Radiology, University of Washington, Seattle, WA 98195, USA; [email protected] Correspondence: [email protected]: Law, J.B.; Comstock, B.A.; Richards, T.L.; Traudt, C.M.; Wood, T.R.; Mayock, D.E.; Heagerty, P.J.; Juul, S.E.; on behalf on the PENUT Trial Consortium. Diffusion Tensor Imaging Modifications Do not Have an effect on Long-Term Neurodevelopment following Early Erythropoietin among Extremely Preterm Infants within the Preterm Erythropoietin Neuroprotection Trial. Brain Sci. 2021, 11, 1360. https:// doi.org/10.3390/brainsci11101360 Academic Editor: Sven M sson Received: 21 September 2021 Accepted: 14 October 2021 Published: 16 OctoberAbstract: We aimed to evaluate diffusion tensor imaging (DTI) in infants born very preterm, to establish the effect of erythropoietin (Epo) on DTI, and to correlate DTI with neurodevelopmental outcomes at 2 years of age for infants inside the Preterm Erythropoietin Neuroprotection (PENUT) Trial. Infants who underwent MRI with DTI at 36 weeks postmenstrual age had been integrated. Neurodevelopmental outcomes had been evaluated by Bayley Scales of Infant and Toddler Improvement (BSID-III). Generalized linear models have been utilized to assess the association amongst DTI parameters and treatment group, then with neurodevelopmental outcomes. A total of 101 placebo- and 93 Epo-treated infants underwent MRI. DTI white matter imply diffusivity (MD) was lower in placebo- in comparison to Epo-treated infants inside the cingulate and DNQX disodium salt site occipital regions, and occipital white matter fractional isotropy (FA) was lower in infants born at 245 weeks vs. 267 weeks. These values weren’t associated with reduced BSID-III scores. Particular decreases in clustering coefficients tended to possess lower BSID-III scores. Constant with the PENUT Trial findings, there was no effect on long-term neurodevelopment in Epo-treated infants even in the presence of microstructural changes identified by DTI. Search phrases: diffusion tensor imaging; preterm; erythropoietin; clustering coefficient1. Introduction Advances in neonatology have led to unprecedented improvements in neonatal survival such that infants born at 22-0/7 to 25-6/7 weeks’ gestation now possess a 70 survival price [1]. However, neurodevelopmental outcomes for exceptionally preterm (EP) infants have not enhanced in the exact same rate. Although a current report suggests that an rising percentage of these born preterm have no big disabilities, up to 40 of survivors born at much less than 28 weeks of gestation nonetheless develop a single or additional complications including cerebral palsy, intellectual disability, visual or auditory deficits.