As is prolonged hospitalization [2, five, 72]. Since the risk components of wound infection are related to components responsible for disturbances in standard healing procedure, it appears affordable to treat each and every case of a chronic, difficult-healing wound as potentially infected. As outlined by the recommendations with the Centers for Disease Handle and Prevention, postoperative wounds in obstetrics and gynecology are classified as clean-contaminated [72]. Literature information estimate the incidence of infected woundsArch Gynecol Obstet (2015) 292:757in obstetrics and gynecology at 1 to 82 [1, 7, 1012]. With regard for the two most common procedures– abdominal hysterectomy and cesarean section, SSIs rates are three.02.two and 1.81.3 , respectively, whilst in women right after surgical remedy of cancer of the vulva, the percentage of wound infections is even greater and amounts to 219 [1, 7, 8, 103]. In most instances, microorganisms accountable for the infections of obstetric and COX-2 Activator Compound gynecological postoperative wounds will be the patient’s endogenous bacterial flora. Most generally isolated strains contain: Staphylococcus aureus, aerobic Gram-negative bacilli (Escherichia coli, Proteus sp., Klebsiella sp., Enterobacter sp.), Enterococcus sp., bhemolyzing streptococci of groups A, B, C and G, anaerobic bacterial species and Pseudomonas aeruginosa [1, 7, ten, 11]. Methicillin-resistant Staphylococcus aureus (MRSA) is detected in 23 inoculates from infected obstetric/gynecological wounds [7, 10, 11]. Fungi, primarily Candida sp. constitute a uncommon etiological aspect in postoperative wound infections in gynecology [7]. Proper management of infected wounds is really a multistage process involving wound debridement, lavasepsis and the use of nearby and/or systemic agents (antiseptics, antibiotics). Inside the era of rising bacterial resistance to antibiotics, topical remedy with antiseptics plays a crucial part, because the agents are less selective but allow to achieve higher therapeutic concentrations inside the wound, specifically in concomitant ischemic situations. Antiseptic dressings are an example of such activity; among these, dressings containing silver are the group of greatest documented efficacy. Antiseptic properties of silver in the treatment of wound infections had been already identified in the ancient instances. Currently, silver dressings are a novel technique for topical therapy of infected and difficult-to-heal wounds. This can be mostly because of the silver’s broad spectrum of antimicrobial action against both fungi and bacteria which includes MRSA or vancomycinresistant enterococci (VRE) [20, 71, 737]. Combined with somewhat low toxicity, aforementioned properties make silver a really valuable tool for fighting pathogens responsible for infections of wounds after iatrogenic activities. The mechanisms of silver action involve inhibition in the cellular respiration, binding of nucleic acids and causing their denaturation, inhibiting cell replication and altering the permeability of microbial cell membranes [20, 71, 73, 74, 78]. This is accomplished by indicates of reactions in the silver ions with proteins, DNA or RNA and negatively charged chloride ions inside pathogens cells. An adverse side of this interaction would be the inactivation of very reactive and positively charged silver ions (Ag) by chlorides and several anionic complexes present in the wound bed. Consequently, a fast drop within the Caspase 1 Inhibitor web concentration of an active kind ofsilver that might effectively inhibit the development of microorganisms accountable for the i.