Es for the prevention of stroke in nonvalvular atrial fibrillation and venous thromboembolism [1]. Even though it was related having a greater reduction in the rate of stroke and also a decrease price of D4 Receptor Agonist supplier bleeding in comparison to warfarin within the ARISTOTLE trial, it was related with an increased threat of major bleeding (like hemopericardium) defined employing the International Society on Thrombosis and Hemostasis (ISTH) criteria; at an incident rate of 2.13 per year [2,3]. Even so, the percentage of hemopericardium compared to other bleeding websites was not integrated inside the trial results [2,3]. Hemopericardium may be the accumulation of blood in the pericardial space [4]. This could cause lifethreatening hemodynamic compromise, cardiac tamponade based on the price and volume of blood accumulation [4]. Reported causes are infection (in particular tuberculosis), metastasis of malignant cells towards the pericardium, thoracic aortic dissection, cardiac surgery, acute myocardial infarction, trauma, pericarditis, and bleeding diathesis [3]. We present a case of hemopericardium in a patient taking apixaban for paroxysmal atrial fibrillation.Evaluation began 01/26/2021 Review ended 02/22/2021 Published 02/22/2021 Copyright 2021 Olagunju et al. This can be an open access article distributed below the terms from the Inventive Commons Attribution License CC-BY four.0., which permits unrestricted use, distribution, and reproduction in any medium, offered the original author and source are credited.Case PresentationAn 80-year-old male using a previous healthcare history of paroxysmal atrial fibrillation, heart failure with preserved ejection fraction, chronic obstructive pulmonary illness, tobacco dependence, benign important hypertension, and stage three chronic kidney illness presented for the emergency division (ED) with shortness of breath, orthopnea, growing lower extremity edema, and cough of two weeks’ duration. The cough was productive with white sputum and worse inside the supine position. He denied hemoptysis, chest discomfort, fever, chills, night sweat, fat reduction, nausea, and vomiting. His paroxysmal atrial fibrillation was diagnosed two weeks prior when he was admitted and treated for COPD exacerbation and cellulitis of your right shin. He converted to sinus rhythm just after receiving 20mg IV diltiazem. Depending on his CHA2DS2VASc score of four, he was discharged property with 5mg twice per day (BID) of apixaban and metoprolol succinate 12.5mg BID for rate control; he was also H4 Receptor Agonist supplier started on amiodarone 200mg daily outpatient. A transthoracic echocardiogram prior to discharge revealed a regular ejection fraction of 62 with grade two diastolic dysfunction (Figure 1).The way to cite this short article Olagunju A, Khatib M, Palermo-Alvarado F (February 22, 2021) A Attainable Drug-Drug Interaction Between Eliquis and Amiodarone Resulting in Hemopericardium. Cureus 13(2): e13486. DOI 10.7759/cureus.FIGURE 1: Parasternal long-axis view of your patient’s baseline echocardiogram didn’t show pericardial effusion.On presentation towards the ED, he was tachypneic using a respiratory price of 32 breaths per minute and oxygen saturation of 91 on space air, his heart price was 77 beats per minute and blood stress was 114/78mmHg. Physical examination was outstanding for jugular venous distention, distant heart sounds, and 3+ bilateral reduced extremity edema up to his shins. Abnormal laboratory findings on admission were hemoglobin of ten.8g/dL (his baseline is 12g/dL), creatinine of 1.67mg/dL (his baseline is 1.42mg/dL), glomerular filtration price.