The stabilization of toll-like receptor 4 mRNA induced by endotoxin. a novel mechanism involved in vascular inflammation. Arterioscler Thromb Vasc. Biol. 2006, 26, 2622629. Hostetter, C.; Licata, L.A.; Witkiewicz, A.; Costantino, C.L.; Yeo, C.J.; Brody, J.R.; Keen, J.C. Cytoplasmic accumulation in the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor constructive breast cancer cells. Cancer Biol. Ther. 2008, 7, 1496506. Costantino, C.L.; Witkiewicz, A.K.; Kuwano, Y.; Cozzitorto, J.A.; Kennedy, E.P.; Dasgupta, A.; Keen, J.C.; Yeo, C.J.; Gorospe, M.; Brody, J.R. The part of HuR in gemcitabine efficacy in pancreatic cancer. HuR Up-regulates the expression with the gemcitabine metabolizing enzyme deoxycytidine kinase. Cancer Res. 2009, 69, 4567572. Chen, L.; Jarujaron, S.; Wu, X.; Sun, L.; Zha, W.; Liang, G.; Wang, X.; Gurley, E.C.; Studer, E.J.; Hylemon, P.B.; et al. HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled towards the unfolded protein response and ERK signaling pathways in macrophages. Biochem. Pharmacol. 2009, 78, 707. Bonelli, M.A.; Alfieri, R.R.; Desenzani, S.; Petronini, P.G.; Borghetti, A.F. Proteasome inhibition increases HuR level, restores heat-inducible HSP72 expression and thermotolerance in WI-38 senescent human fibroblasts. Exp. Gerontol. 2004, 39, 42332. Levy, N.S.; Chung, S.; Furneaux, H.; Levy, A.P. Hypoxic stabilization of vascular endothelial growth aspect mRNA by the RNA-binding protein HuR. J. Biol. Chem. 1998, 273, 6417423. Yaman, I.; Fernandez, J.; Sarkar, B.; Schneider, R.J.; Snider, M.D.; Nagy, L.E.; Hatzoglou, M. Nutritional handle of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR. J. Biol. Chem. 2002, 277, 415391546. Perrone, E.E.; Liu, L.; Turner, D.J.; Strauch, E.D. Bile salts improve epithelial cell proliferation by means of HuR-induced c-Myc expression. J. Surg. Res. 2012, 178, 15561. Atasoy, U.; Watson, J.; Patel, D.; Keene, J.D. ELAV protein HuA (HuR) can redistribute among nucleus and cytoplasm and is upregulated through serum stimulation and T cell activation. J. Cell Sci. 1998, 111, 3145156. Zou, T.; Rao, J.N.; Liu, L.; Xiao, L.; Yu, T.X.; Jiang, P.; Gorospe, M.; Wang, J.Y. Polyamines regulate the stability of JunD mRNA by modulating the competitive binding of its 3′ untranslated region to HuR and AUF1. Mol. Cell Biol. 2010, 30, 5021032. Zou, T.; Liu, L.; Rao, J.N.; Marasa, B.S.; Chen, J.; Xiao, L.; Zhou, H.; Gorospe, M.; Wang, J.Y. Polyamines modulate the subcellular localization of RNA-binding protein HuR via AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1.Roxadustat Biochem.Aprocitentan J.PMID:34337881 2008, 409, 38998.Int. J. Mol. Sci. 2013, 14 43.44.45.46.47.48.49.50.51.52.53. 54.55.Zou, T.; Mazan-Mamczarz, K.; Rao, J.N.; Liu, L.; Marasa, B.S.; Zhang, A.H.; Xiao, L.; Pullmann, R.; Gorospe, M.; Wang, J.Y. Polyamine depletion increases cytoplasmic levels of RNA-binding protein HuR top to stabilization of nucleophosmin and p53 mRNAs. J. Biol. Chem. 2006, 281, 193879394. Serini, S.; Fasano, E.; Piccioni, E.; Monego, G.; Cittadini, A.R.; Celleno, L.; Ranelletti, F.O.; Calviello, G. DHA induces apoptosis and differentiation in human melanoma cells in vitro. involvement of HuR-mediated COX-2 mRNA stabilization and beta-catenin nuclear translocation. Carcinogenesis 2012, 33, 16473. Cao, H.; Kelly, M.A.; Kari, F.; Dawson, H.D.; Urban, J.F., Jr.; Coves, S.; Roussel, A.M.; Ander.