Product Name :
ND-630
CAS No.:
1434635-54-7
Purity :
> 99%
Shipping:
Shipped at room temperature.
Storage :
Store at -20 °C for up to a year. Dissolve in anhydrous DMSO and store DMSO stock solutions at 4 °C for a couple of days or store stock solutions at -20 °C in aliquots for up to a month. Avoid freeze/thaw cycles of solutions.
SMILES:
Product Description :
ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC. Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks the ability to inhibit other mechanistically-related enzymes. In rats with diet-induced obesity, ND-630 reduced hepatic steatosis, improved insulin sensitivity, and reduced weight gain, suggesting ACC inhibition may be useful in treating metabolic disorders, including type 2 diabetes mellitus, and fatty liver disease.
Formula:
C28H31N3O8S
Molecular Weight :
569.63
Synonyms:
ND630 ACC1 ACC2
Additional Information:
|CAS No. 1434635-54-7 ; |Synonyms ND630 ACC1 ACC2 ; |Formula C28H31N3O8S ; |Molecular Weight 569.63 ; |Product Description ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC.Tapinarof Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks the ability to inhibit other mechanistically-related enzymes.Interferon alfa In rats with diet-induced obesity, ND-630 reduced hepatic steatosis, improved insulin sensitivity, and reduced weight gain, suggesting ACC inhibition may be useful in treating metabolic disorders, including type 2 diabetes mellitus, and fatty liver disease.PMID:23991096 ; |Format Solid ; |Purity > 99% ; |Shipping Shipped at room temperature. ; |Storage Store at -20 °C for up to a year. Dissolve in anhydrous DMSO and store DMSO stock solutions at 4 °C for a couple of days or store stock solutions at -20 °C in aliquots for up to a month. Avoid freeze/thaw cycles of solutions. ; |Solubility Overview Soluble in DMSO