Product Name :
NLG919
CAS No.:
1402836-58-1
Purity :
> 98%
Shipping:
Shipped on dry ice.
Storage :
Store as supplied at or below -20 °C for up to 3 years. Stable in DMSO at -80 °C for up to 6 months.
SMILES:
Product Description :
NLG919 is an orally available potent inhibitor of the indoleamine-2,3- dioxygenase (IDO1) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2, mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for the treatment of immunosuppression associated with cancer.
Formula:
C18H22N2O
Molecular Weight :
282.4
Synonyms:
1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol, IDO inhibitor
Additional Information:
|CAS No.{{Dihydroartemisinin} site|{Dihydroartemisinin} Apoptosis|{Dihydroartemisinin} Purity & Documentation|{Dihydroartemisinin} Description|{Dihydroartemisinin} custom synthesis|{Dihydroartemisinin} Cancer} 1402836-58-1 ; |Synonyms 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol, IDO inhibitor ; |Formula C18H22N2O ; |Molecular Weight 282.{{Ganglioside GM3} site|{Ganglioside GM3} Technical Information|{Ganglioside GM3} In stock|{Ganglioside GM3} custom synthesis|{Ganglioside GM3} Epigenetic Reader Domain} 4 ; |Target IDO1 ; |Product Description NLG919 is an orally available potent inhibitor of the indoleamine-2,3- dioxygenase (IDO1) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine.PMID:25959043 NLG919 affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2, mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for the treatment of immunosuppression associated with cancer. ; |Format Solid ; |Purity > 98% ; |Shipping Shipped on dry ice. ; |Storage Store as supplied at or below -20 °C for up to 3 years. Stable in DMSO at -80 °C for up to 6 months. ; |Solubility Overview Soluble in DMSO at 15 mg/mL.