Product Name :
MARK-IN-1
Description:
MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of <0.25 nM.
CAS:
1109283-93-3
Molecular Weight:
471.53
Formula:
C22H23F2N7OS
Chemical Name:
N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide
Smiles :
CN1C=C(C=N1)C1=CN2N=CC(=C2N=C1)C1C=C(SC=1C)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F
InChiKey:
SFILVHFYISPBOI-IEBWSBKVSA-N
InChi :
InChI=1S/C22H23F2N7OS/c1-12-15(6-18(33-12)21(32)29-19-17(25)4-3-5-22(19,23)24)16-9-28-31-11-13(7-26-20(16)31)14-8-27-30(2)10-14/h6-11,17,19H,3-5,25H2,1-2H3,(H,29,32)/t17-,19-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Tafamidis} MedChemExpress|{Tafamidis} Neuronal Signaling|{Tafamidis} Biological Activity|{Tafamidis} Purity|{Tafamidis} custom synthesis|{Tafamidis} Cancer}
Shelf Life:
≥12 months if stored properly.{{SP-13786} site|{SP-13786} Technical Information|{SP-13786} In Vivo|{SP-13786} manufacturer|{SP-13786} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of Product information|CAS Number: 1109283-93-3|Molecular Weight: 471.53|Formula: C22H23F2N7OS|Chemical Name: N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-5-methyl-4-[6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidin-3-yl]thiophene-2-carboxamide|Smiles: CN1C=C(C=N1)C1=CN2N=CC(=C2N=C1)C1C=C(SC=1C)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F|InChiKey: SFILVHFYISPBOI-IEBWSBKVSA-N|InChi: InChI=1S/C22H23F2N7OS/c1-12-15(6-18(33-12)21(32)29-19-17(25)4-3-5-22(19,23)24)16-9-28-31-11-13(7-26-20(16)31)14-8-27-30(2)10-14/h6-11,17,19H,3-5,25H2,1-2H3,(H,29,32)/t17-,19-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23546012 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MARK-IN-1 (Compound 25) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer’s disease.|Products are for research use only. Not for human use.|