Product Name :
Dipraglurant
Description:
Dipraglurant, aslo known as ADX-48621, is a negative allosteric modulator of the mGlu5 receptor which is under development by Addex Therapeutics for the treatment of Parkinson’s disease levodopa-induced dyskinesia (PD-LID). Blocking metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for levodopa-induced dyskinesias (LID) in Parkinson’s disease (PD). Acute challenges of dipraglurant were efficacious on choreic and dystonic LID in the MPTP-macaque model.
CAS:
872363-17-2
Molecular Weight:
265.28
Formula:
C16H12FN3
Chemical Name:
2-(4-{6-fluoroimidazo[1,2-a]pyridin-2-yl}but-1-yn-1-yl)pyridine
Smiles :
FC1=CN2C=C(CCC#CC3=CC=CC=N3)N=C2C=C1
InChiKey:
LZXMUJCJAWVHPZ-UHFFFAOYSA-N
InChi :
InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Dipraglurant, aslo known as ADX-48621, is a negative allosteric modulator of the mGlu5 receptor which is under development by Addex Therapeutics for the treatment of Parkinson’s disease levodopa-induced dyskinesia (PD-LID). Blocking metabotropic glutamate receptor type 5 (mGluR5) has been proposed as a target for levodopa-induced dyskinesias (LID) in Parkinson’s disease (PD). Acute challenges of dipraglurant were efficacious on choreic and dystonic LID in the MPTP-macaque model.|Product information|CAS Number: 872363-17-2|Molecular Weight: 265.{{Coelenterazine} site|{Coelenterazine} NF-κB|{Coelenterazine} Technical Information|{Coelenterazine} Data Sheet|{Coelenterazine} supplier|{Coelenterazine} Autophagy} 28|Formula: C16H12FN3|Chemical Name: 2-(4-{6-fluoroimidazo[1,2-a]pyridin-2-yl}but-1-yn-1-yl)pyridine|Smiles: FC1=CN2C=C(CCC#CC3=CC=CC=N3)N=C2C=C1|InChiKey: LZXMUJCJAWVHPZ-UHFFFAOYSA-N|InChi: InChI=1S/C16H12FN3/c17-13-8-9-16-19-15(12-20(16)11-13)7-2-1-5-14-6-3-4-10-18-14/h3-4,6,8-12H,2,7H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Reproxalap} medchemexpress|{Reproxalap} Biological Activity|{Reproxalap} In Vivo|{Reproxalap} supplier|{Reproxalap} Cancer} |Shelf Life: ≥360 days if stored properly.PMID:34337881 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|