Product Name :
PF-07247685
CAS No.:
Purity :
99.57%
Shipping:
Room temperature in the continental U.S. Other areas may vary.
Storage :
Powder: -20°C, 3 years; 4°C, 2 yearsIn solvent: -80°C, 6 months; -20°C, 1 month
SMILES:
O=C(O)C1=CC=CC=C1C2=NC(C3=CC=C(OCC4(CC4)CC)N=C3)=CS2
Product Description :
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice.
Formula:
C21H20N2O3S
Molecular Weight :
380.46
Synonyms:
Additional Information:
|Formula C21H20N2O3S ; |Molecular Weight 380.46 ; |SMILES O=C(O)C1=CC=CC=C1C2=NC(C3=CC=C(OCC4(CC4)CC)N=C3)=CS2 ; |Target Endogenous Metabolite ; |Product Description PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC50=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation.{{Bombesin} site|{Bombesin} GPCR/G Protein|{Bombesin} Technical Information|{Bombesin} Formula|{Bombesin} supplier|{Bombesin} Cancer} Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity.{{Cyproheptadine} MedChemExpress|{Cyproheptadine} Apoptosis|{Cyproheptadine} Technical Information|{Cyproheptadine} Description|{Cyproheptadine} supplier|{Cyproheptadine} Autophagy} PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice.PMID:24065671 ; |Format Solid ; |Color White to off-white ; |Purity 99.57% ; |Shipping Room temperature in the continental U.S. Other areas may vary. ; |Storage Powder: -20°C, 3 years; 4°C, 2 yearsIn solvent: -80°C, 6 months; -20°C, 1 month ; |Solubility Overview Soluble in DMSO