Product Name :
PF-5274857
CAS No.:
1373615-35-0
Purity :
> 98%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CC[S](C)(=O)=O)C
Product Description :
PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.{{Lazertinib} medchemexpress|{Lazertinib} EGFR|{Lazertinib} Biological Activity|{Lazertinib} Purity|{Lazertinib} supplier|{Lazertinib} Autophagy} 8 nM and 4.{{Drotaverine} site|{Drotaverine} Calcium Channel|{Drotaverine} Purity & Documentation|{Drotaverine} References|{Drotaverine} manufacturer|{Drotaverine} Autophagy} 6 nM, respectively, and can penetrate the blood–brain barrier.PMID:24406011
Formula:
C20H25ClN4O3S
Molecular Weight :
436.96
Synonyms:
Additional Information:
|CAS No. 1373615-35-0 ; |Formula C20H25ClN4O3S ; |Molecular Weight 436.96 ; |SMILES CC1=CC(=C(N=C1)C2=CC(=NC=C2Cl)N3CCN(CC3)C(=O)CC[S](C)(=O)=O)C ; |Product Description PF-5274857 is a potent and selective Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 and Ki of 5.8 nM and 4.6 nM, respectively, and can penetrate the blood–brain barrier. ; |Purity > 98% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO