Product Name :
Silybin
Description:
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.
CAS:
802918-57-6
Molecular Weight:
482.44
Formula:
C25H22O10
Chemical Name:
(2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one
Smiles :
COC1=CC(=CC=C1O)C1OC2=CC(=CC=C2OC1CO)[C@H]1OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
InChiKey:
SEBFKMXJBCUCAI-DBMPWETRSA-N
InChi :
InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amcenestrant} web|{Amcenestrant} Estrogen Receptor/ERR|{Amcenestrant} Biological Activity|{Amcenestrant} In stock|{Amcenestrant} manufacturer|{Amcenestrant} Autophagy}
Shelf Life:
≥12 months if stored properly.{{RF9} site|{RF9} Neuropeptide Y Receptor|{RF9} Biological Activity|{RF9} In stock|{RF9} custom synthesis|{RF9} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:34235739
Additional information:
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity.|Product information|CAS Number: 802918-57-6|Molecular Weight: 482.44|Formula: C25H22O10|Chemical Name: (2R,3R)-3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one|Smiles: COC1=CC(=CC=C1O)C1OC2=CC(=CC=C2OC1CO)[C@H]1OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O|InChiKey: SEBFKMXJBCUCAI-DBMPWETRSA-N|InChi: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20?,23-,24?,25+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Silybin (0-200 mM; for 72 hours) has growth inhibition in a time- and dose-dependent manner. Silybin (68 μM; for 72 hours) induces apoptosis and increases the cells in G1-phase of ~22%. Silybin (68 μM; for 72 hours) induces AKT activity inhibition.|In Vivo:|Silybin (50, 100 mg/kg/day; given intragastrically for the last 4 weeks) significantly lowers both serum and hepatic lipid accumulation.|Products are for research use only. Not for human use.|