Product Name :
Praeruptorin A
CAS No.:
73069-25-7
Purity :
> 97%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
C\C=C(C)/C(=O)OC1C(OC(C)=O)C2=C(OC1(C)C)C=CC3=C2OC(=O)C=C3
Product Description :
Praeruptorin A may exert antiinflammatory effects in vitro in LPS-stimulated RAW 264.7 macrophages through inhibition of NF-κB signal pathway activation. Praeruptorin A and praeruptorin C can significantly up-regulate UGT1A1 expression in HepG2 cells partially via the CAR-mediated pathway.(+)-Praeruptorin A exerts distinct relaxant effects on isolated rat aorta rings, which may be mainly attributed to nitric oxide synthesis catalyzed by endothelial nitric oxide synthase.{{Olesoxime} site|{Olesoxime} Metabolic Enzyme/Protease|{Olesoxime} Biological Activity|{Olesoxime} References|{Olesoxime} supplier|{Olesoxime} Autophagy} dl-Praeruptorin A has a neuroprotective effect on the injury in the acute phase of transient focal cerebral ischemia in mice,with optimal doses of 5 mg/kg and the optimal therapeutic time point of the same time of reperfusion.dl-Praeruptorin A elicits a novel target in the therapeutic prevention of postischemic cardiomyocyte death, the reason might be associated with modulating the expression of some immediate-early genes including IL-6, Fas, bax, and bcl-2 in ischemia-reperfusion myocardium.Praeruptorin A upregulates expression of nestin in experimental autoimmune myocarditis of rats, it is beneficial to facilitate nestin expression in myocarditis,and suitable in treatment of early myocarditis.{{Griseofulvin} site|{Griseofulvin} Anti-infection|{Griseofulvin} Purity & Documentation|{Griseofulvin} In stock|{Griseofulvin} supplier|{Griseofulvin} Epigenetics} Praeruptorin A has anti-osteoclastogenic activity via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation.PMID:24605203
Formula:
C21H22O7
Molecular Weight :
386.4
Synonyms:
Additional Information:
|CAS No. 73069-25-7 ; |Formula C21H22O7 ; |Molecular Weight 386.4 ; |SMILES C\C=C(C)/C(=O)OC1C(OC(C)=O)C2=C(OC1(C)C)C=CC3=C2OC(=O)C=C3 ; |Product Description Praeruptorin A may exert antiinflammatory effects in vitro in LPS-stimulated RAW 264.7 macrophages through inhibition of NF-κB signal pathway activation. Praeruptorin A and praeruptorin C can significantly up-regulate UGT1A1 expression in HepG2 cells partially via the CAR-mediated pathway.(+)-Praeruptorin A exerts distinct relaxant effects on isolated rat aorta rings, which may be mainly attributed to nitric oxide synthesis catalyzed by endothelial nitric oxide synthase. dl-Praeruptorin A has a neuroprotective effect on the injury in the acute phase of transient focal cerebral ischemia in mice,with optimal doses of 5 mg/kg and the optimal therapeutic time point of the same time of reperfusion.dl-Praeruptorin A elicits a novel target in the therapeutic prevention of postischemic cardiomyocyte death, the reason might be associated with modulating the expression of some immediate-early genes including IL-6, Fas, bax, and bcl-2 in ischemia-reperfusion myocardium.Praeruptorin A upregulates expression of nestin in experimental autoimmune myocarditis of rats, it is beneficial to facilitate nestin expression in myocarditis,and suitable in treatment of early myocarditis.Praeruptorin A has anti-osteoclastogenic activity via inhibition of p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca2+ oscillation. ; |Purity > 97% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO