Product Name :
JHU 37160
Description:
JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. It is a brain penetrant in mice, rats and non-human primates.
CAS:
2369979-68-8
Molecular Weight:
358.84
Formula:
C19H20ClFN4
Chemical Name:
8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b, e][1, 4]diazepine
Smiles :
CCN1CCN(CC1)C1=NC2=CC(Cl)=CC=C2NC2=C(F)C=CC=C21
InChiKey:
SWSCWOSASZXIRK-UHFFFAOYSA-N
InChi :
InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites.{{Tedizolid} medchemexpress|{Tedizolid} Anti-infection|{Tedizolid} Purity & Documentation|{Tedizolid} Purity|{Tedizolid} supplier|{Tedizolid} Cancer} JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. It is a brain penetrant in mice, rats and non-human primates.|Product information|CAS Number: 2369979-68-8|Molecular Weight: 358.84|Formula: C19H20ClFN4|Synonym:|JHU37160|JHU-37160|Chemical Name: 8-Chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b, e][1, 4]diazepine|Smiles: CCN1CCN(CC1)C1=NC2=CC(Cl)=CC=C2NC2=C(F)C=CC=C21|InChiKey: SWSCWOSASZXIRK-UHFFFAOYSA-N|InChi: InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3|Technical Data|Appearance: Solid Power.{{Pitavastatin} medchemexpress|{Pitavastatin} Autophagy|{Pitavastatin} Protocol|{Pitavastatin} In stock|{Pitavastatin} custom synthesis|{Pitavastatin} Cancer} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23667820 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Bonaventura et al (2019) High-potency ligands for DREADD imaging and activation in rodents and monkeys. Nat.Commun. 10 4627 PMID: 31604917Products are for research use only. Not for human use.|