Product Name :
DT2216
Description:
DT2216 is a potent and selective degrader of BCL-XL based on PROTAC technology. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets.
CAS:
2365172-42-3
Molecular Weight:
1542.36
Formula:
C77H96ClF3N10O10S4
Chemical Name:
(2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4′-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
Smiles :
CC(C)(C)[C@H](NC(=O)CCCCCC(=O)N1CCN(CC[C@H](CSC2C=CC=CC=2)NC2=CC=C(C=C2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C2C=CC(=CC=2)N2CCN(CC2)CC2CC(C)(C)CCC=2C2C=CC(Cl)=CC=2)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)C1C=CC(=CC=1)C1SC=NC=1C
InChiKey:
PXVFFBGSTYQHRO-REQIQPEASA-N
InChi :
InChI=1S/C77H96ClF3N10O10S4/c1-51(53-18-20-55(21-19-53)70-52(2)82-50-103-70)83-73(96)66-44-61(92)48-91(66)74(97)71(75(3,4)5)85-68(93)16-12-9-13-17-69(94)90-42-36-87(37-43-90)35-33-59(49-102-62-14-10-8-11-15-62)84-65-31-30-63(45-67(65)104(98,99)77(79,80)81)105(100,101)86-72(95)56-24-28-60(29-25-56)89-40-38-88(39-41-89)47-57-46-76(6,7)34-32-64(57)54-22-26-58(78)27-23-54/h8,10-11,14-15,18-31,45,50-51,59,61,66,71,84,92H,9,12-13,16-17,32-44,46-49H2,1-7H3,(H,83,96)(H,85,93)(H,86,95)/t51-,59+,61+,66-,71+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{BHQ-880} site|{BHQ-880} TGF-beta/Smad|{BHQ-880} Protocol|{BHQ-880} In stock|{BHQ-880} custom synthesis}
Additional information:
DT2216 is a potent and selective degrader of BCL-XL based on PROTAC technology. DT2216 inhibits various BCL-XL-dependent leukemia and cancer cells but considerably less toxic to platelets.|Product information|CAS Number: 2365172-42-3|Molecular Weight: 1542.36|Formula: C77H96ClF3N10O10S4|Chemical Name: (2S,4R)-1-((S)-2-(7-(4-((R)-3-((4-(N-(4-(4-((4′-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoyl)sulfamoyl)-2-((trifluoromethyl)sulfonyl)phenyl)amino)-4-(phenylthio)butyl)piperazin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide|Smiles: CC(C)(C)[C@H](NC(=O)CCCCCC(=O)N1CCN(CC[C@H](CSC2C=CC=CC=2)NC2=CC=C(C=C2S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)C2C=CC(=CC=2)N2CCN(CC2)CC2CC(C)(C)CCC=2C2C=CC(Cl)=CC=2)CC1)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](C)C1C=CC(=CC=1)C1SC=NC=1C|InChiKey: PXVFFBGSTYQHRO-REQIQPEASA-N|InChi: InChI=1S/C77H96ClF3N10O10S4/c1-51(53-18-20-55(21-19-53)70-52(2)82-50-103-70)83-73(96)66-44-61(92)48-91(66)74(97)71(75(3,4)5)85-68(93)16-12-9-13-17-69(94)90-42-36-87(37-43-90)35-33-59(49-102-62-14-10-8-11-15-62)84-65-31-30-63(45-67(65)104(98,99)77(79,80)81)105(100,101)86-72(95)56-24-28-60(29-25-56)89-40-38-88(39-41-89)47-57-46-76(6,7)34-32-64(57)54-22-26-58(78)27-23-54/h8,10-11,14-15,18-31,45,50-51,59,61,66,71,84,92H,9,12-13,16-17,32-44,46-49H2,1-7H3,(H,83,96)(H,85,93)(H,86,95)/t51-,59+,61+,66-,71+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO 100 mg/mL (64.{{Phenformin} web|{Phenformin} PI3K/Akt/mTOR|{Phenformin} Immunology/Inflammation|{Phenformin} Protocol|{Phenformin} Data Sheet|{Phenformin} manufacturer} 84 mM) Ethanol 100 mg/mL (64.PMID:24367939 84 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|