Product Name :
PF-07304814
Description:
PF-07304814, a phosphate prodrug of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. PF-07304814 binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. PF-07304814 is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle.
CAS:
2468015-78-1
Molecular Weight:
552.51
Formula:
C24H33N4O9P
Chemical Name:
[(3S)-3-[[(2S)-2-[(4-methoxy-1H-indole-2-carbonyl)amino]-4-methylpentanoyl]amino]-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl] dihydrogen phosphate
Smiles :
CC(C)C[C@H](NC(=O)C1=CC2C(=CC=CC=2N1)OC)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COP(O)(O)=O
InChiKey:
FQKALOFOWPDTED-WBAXXEDZSA-N
InChi :
InChI=1S/C24H33N4O9P/c1-13(2)9-18(28-24(32)19-11-15-16(26-19)5-4-6-21(15)36-3)23(31)27-17(10-14-7-8-25-22(14)30)20(29)12-37-38(33,34)35/h4-6,11,13-14,17-18,26H,7-10,12H2,1-3H3,(H,25,30)(H,27,31)(H,28,32)(H2,33,34,35)/t14-,17-,18-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
PF-07304814, a phosphate prodrug of PF-00835231, acts as a potent 3CLpro protease (Mpro) inhibitor with SARS-CoV-2 antiviral activity. PF-07304814 binds and inhibits SARS-CoV-2 3CLpro activity with a Ki of 174nM. PF-07304814 is promising single antiviral agent and also can be used for the research of combination with other antivirals that target other critical stages of the coronavirus life cycle.|Product information|CAS Number: 2468015-78-1|Molecular Weight: 552.51|Formula: C24H33N4O9P|Chemical Name: [(3S)-3-[[(2S)-2-[(4-methoxy-1H-indole-2-carbonyl)amino]-4-methylpentanoyl]amino]-2-oxo-4-[(3S)-2-oxopyrrolidin-3-yl]butyl] dihydrogen phosphate|Smiles: CC(C)C[C@H](NC(=O)C1=CC2C(=CC=CC=2N1)OC)C(=O)N[C@@H](C[C@@H]1CCNC1=O)C(=O)COP(O)(O)=O|InChiKey: FQKALOFOWPDTED-WBAXXEDZSA-N|InChi: InChI=1S/C24H33N4O9P/c1-13(2)9-18(28-24(32)19-11-15-16(26-19)5-4-6-21(15)36-3)23(31)27-17(10-14-7-8-25-22(14)30)20(29)12-37-38(33,34)35/h4-6,11,13-14,17-18,26H,7-10,12H2,1-3H3,(H,25,30)(H,27,31)(H,28,32)(H2,33,34,35)/t14-,17-,18-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Aldosterone} web|{Aldosterone} Metabolic Enzyme/Protease|{Aldosterone} Biological Activity|{Aldosterone} In Vitro|{Aldosterone} supplier|{Aldosterone} Cancer} |Shelf Life: ≥12 months if stored properly.{{Belimumab} medchemexpress|{Belimumab} Immunology/Inflammation|{Belimumab} Protocol|{Belimumab} Description|{Belimumab} supplier|{Belimumab} Cancer} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23008002 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Once administered through intravenous infusion, PF-07304814 is cleaved into PF-00835231 to exert its anti-viral effects. PF-07304814 exhibits a favorable cardiovascular safety profile. PF-07304814 is administered intravenously to rats, dogs and monkeys. It exhibits high systemic clearance and short half-life across species forming 68, 81, 76% PF-00835231 in rats, dogs and monkey respectively in comparison to the systemic exposure achieved with IV administration of PF00835231.|Products are for research use only. Not for human use.|