Product Name :
Fumarate hydratase-IN-1
Description:
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM.
CAS:
1644060-37-6
Molecular Weight:
446.54
Formula:
C27H30N2O4
Chemical Name:
ethyl (3S,3aR)-1-({[1,1′-biphenyl]-4-yl}methyl)-3-[(methylcarbamoyl)methyl]-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indole-3a-carboxylate
Smiles :
CCOC(=O)[C@@]12CCCC=C1N(CC1C=CC(=CC=1)C1C=CC=CC=1)C(=O)[C@H]2CC(=O)NC
InChiKey:
VFGLXHHVYNTCPD-AJTFRIOCSA-N
InChi :
InChI=1S/C27H30N2O4/c1-3-33-26(32)27-16-8-7-11-23(27)29(25(31)22(27)17-24(30)28-2)18-19-12-14-21(15-13-19)20-9-5-4-6-10-20/h4-6,9-15,22H,3,7-8,16-18H2,1-2H3,(H,28,30)/t22-,27-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM.|Product information|CAS Number: 1644060-37-6|Molecular Weight: 446.54|Formula: C27H30N2O4|Chemical Name: ethyl (3S,3aR)-1-({[1,1′-biphenyl]-4-yl}methyl)-3-[(methylcarbamoyl)methyl]-2-oxo-2,3,3a,4,5,6-hexahydro-1H-indole-3a-carboxylate|Smiles: CCOC(=O)[C@@]12CCCC=C1N(CC1C=CC(=CC=1)C1C=CC=CC=1)C(=O)[C@H]2CC(=O)NC|InChiKey: VFGLXHHVYNTCPD-AJTFRIOCSA-N|InChi: InChI=1S/C27H30N2O4/c1-3-33-26(32)27-16-8-7-11-23(27)29(25(31)22(27)17-24(30)28-2)18-19-12-14-21(15-13-19)20-9-5-4-6-10-20/h4-6,9-15,22H,3,7-8,16-18H2,1-2H3,(H,28,30)/t22-,27-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (111.{{Dantrolene} site|{Dantrolene} Autophagy|{Dantrolene} Protocol|{Dantrolene} In Vitro|{Dantrolene} custom synthesis|{Dantrolene} Autophagy} 97 mM; Need ultrasonic).{{Crizanlizumab} MedChemExpress|{Crizanlizumab} P-selectin|{Crizanlizumab} Purity & Documentation|{Crizanlizumab} References|{Crizanlizumab} manufacturer|{Crizanlizumab} Autophagy} H2O : Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:34645436 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Fumarate hydratase-IN-1 inhibits SW620, ACHN, HCT-116, PC3, and SK-MEL-28 cell lines with a mean IC50 of 2.2 μM.|Products are for research use only. Not for human use.|