Product Name :
RAF265 (CHIR-265)
CAS No.:
927880-90-8
Purity :
> 99%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
C[N]1C(=NC2=C1C=CC(=C2)OC3=CC=NC(=C3)C4=NC=C([NH]4)C(F)(F)F)NC5=CC=C(C=C5)C(F)(F)F
Product Description :
RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays.{{Deferasirox} web|{Deferasirox} Apoptosis|{Deferasirox} Purity & Documentation|{Deferasirox} Formula|{Deferasirox} custom synthesis|{Deferasirox} Autophagy} Phase 2.{{Olacaftor} web|{Olacaftor} CFTR|{Olacaftor} Technical Information|{Olacaftor} Data Sheet|{Olacaftor} manufacturer|{Olacaftor} Epigenetic Reader Domain}
Formula:
C24H16F6N6O
Molecular Weight :
518.PMID:23880095 41
Synonyms:
Additional Information:
|CAS No. 927880-90-8 ; |Formula C24H16F6N6O ; |Molecular Weight 518.41 ; |SMILES C[N]1C(=NC2=C1C=CC(=C2)OC3=CC=NC(=C3)C4=NC=C([NH]4)C(F)(F)F)NC5=CC=C(C=C5)C(F)(F)F ; |Product Description RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. Phase 2. ; |Purity > 99% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO