Product Name :
RAF709
CAS No.:
1628838-42-5
Purity :
> 99%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
CC1=NC=C(NC(=O)C2=CC=CC(=C2)C(F)(F)F)C=C1C3=CC(=C(OC4CCOCC4)N=C3)N5CCOCC5
Product Description :
RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.{{PLP 139-151} medchemexpress|{PLP 139-151} Purity & Documentation|{PLP 139-151} References|{PLP 139-151} supplier|{PLP 139-151} Autophagy} 4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.
Formula:
C28H29F3N4O4
Molecular Weight :
542.55
Synonyms:
Additional Information:
|CAS No. 1628838-42-5 ; |Formula C28H29F3N4O4 ; |Molecular Weight 542.55 ; |SMILES CC1=NC=C(NC(=O)C2=CC=CC(=C2)C(F)(F)F)C=C1C3=CC(=C(OC4CCOCC4)N=C3)N5CCOCC5 ; |Product Description RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.{{Eribulin} site|{Eribulin} Microtubule/Tubulin|{Eribulin} Protocol|{Eribulin} Purity|{Eribulin} supplier|{Eribulin} Epigenetics} ; |Purity > 99% ; |Shipping Shipped on dry ice.PMID:24883330 ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO