Product Name :
DLK-IN-1
Description:
DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.
CAS:
1620574-24-4
Molecular Weight:
423.43
Formula:
C20H24F3N5O2
Chemical Name:
5-{5-[(1R,5S,6S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(propan-2-yl)-1H-pyrazol-3-yl}-3-(trifluoromethoxy)pyridin-2-amine
Smiles :
CC(C)N1N=C(C=C1[C@@H]1[C@H]2CN(C[C@H]21)C1COC1)C1=CN=C(N)C(=C1)OC(F)(F)F
InChiKey:
UHEFRVBGJORHNV-UOIKSKOESA-N
InChi :
InChI=1S/C20H24F3N5O2/c1-10(2)28-16(18-13-6-27(7-14(13)18)12-8-29-9-12)4-15(26-28)11-3-17(19(24)25-5-11)30-20(21,22)23/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Inotuzumab} medchemexpress|{Inotuzumab} ADC Antibody|{Inotuzumab} Technical Information|{Inotuzumab} Purity|{Inotuzumab} custom synthesis|{Inotuzumab} Epigenetic Reader Domain}
Additional information:
DLK-IN-1 is a selective, orally active inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM.{{Lincomycin hydrochloride} web|{Lincomycin hydrochloride} Bacterial|{Lincomycin hydrochloride} Technical Information|{Lincomycin hydrochloride} In stock|{Lincomycin hydrochloride} custom synthesis|{Lincomycin hydrochloride} Autophagy} DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain.PMID:23892407 DLK-IN-1 has activity in a model of Alzheimer’s Disease.|Product information|CAS Number: 1620574-24-4|Molecular Weight: 423.43|Formula: C20H24F3N5O2|Chemical Name: 5-{5-[(1R,5S,6S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-(propan-2-yl)-1H-pyrazol-3-yl}-3-(trifluoromethoxy)pyridin-2-amine|Smiles: CC(C)N1N=C(C=C1[C@@H]1[C@H]2CN(C[C@H]21)C1COC1)C1=CN=C(N)C(=C1)OC(F)(F)F|InChiKey: UHEFRVBGJORHNV-UOIKSKOESA-N|InChi: InChI=1S/C20H24F3N5O2/c1-10(2)28-16(18-13-6-27(7-14(13)18)12-8-29-9-12)4-15(26-28)11-3-17(19(24)25-5-11)30-20(21,22)23/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,25)/t13-,14+,18+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.5 mg/mL (147.60 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|