Product Name :
AGN 194078
Description:
AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.
CAS:
321995-62-4
Molecular Weight:
403.42
Formula:
C22H23F2NO4
Chemical Name:
2,6-difluoro-4-(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-amido)benzoic acid
Smiles :
CC1(C)CCC(C)(C)C2=CC(C(=O)NC3=CC(F)=C(C(F)=C3)C(O)=O)=C(O)C=C12
InChiKey:
BCKLKOYFMACAMZ-UHFFFAOYSA-N
InChi :
InChI=1S/C22H23F2NO4/c1-21(2)5-6-22(3,4)14-10-17(26)12(9-13(14)21)19(27)25-11-7-15(23)18(20(28)29)16(24)8-11/h7-10,26H,5-6H2,1-4H3,(H,25,27)(H,28,29)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Narazaciclib} MedChemExpress|{Narazaciclib} Epigenetics|{Narazaciclib} TGF-beta/Smad|{Narazaciclib} Technical Information|{Narazaciclib} References|{Narazaciclib} supplier}
Shelf Life:
≥12 months if stored properly.{{Donepezil} MedChemExpress|{Donepezil} Cholinesterase (ChE)|{Donepezil} Protocol|{Donepezil} In Vivo|{Donepezil} custom synthesis|{Donepezil} Cancer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23577779
Additional information:
AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively.|Product information|CAS Number: 321995-62-4|Molecular Weight: 403.42|Formula: C22H23F2NO4|Chemical Name: 2,6-difluoro-4-(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalene-2-amido)benzoic acid|Smiles: CC1(C)CCC(C)(C)C2=CC(C(=O)NC3=CC(F)=C(C(F)=C3)C(O)=O)=C(O)C=C12|InChiKey: BCKLKOYFMACAMZ-UHFFFAOYSA-N|InChi: InChI=1S/C22H23F2NO4/c1-21(2)5-6-22(3,4)14-10-17(26)12(9-13(14)21)19(27)25-11-7-15(23)18(20(28)29)16(24)8-11/h7-10,26H,5-6H2,1-4H3,(H,25,27)(H,28,29)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AGN 194078 is a selective RARα agonist and binds to RARα with very high affinity, having a Kd value of 3 nM, while being unable to bind to RARβ and binding only very weakly (Kd=5600 nM) to RARγ. Furthermore, AGN 194078 maintains full transcriptional activity through RARα, with an EC50 value of 112 nM, but only activatedRARβ and RARγ with about 10% efficacy at the highest dose (1000 nM) tested.|Products are for research use only. Not for human use.|