Product Name :
(+)-U-50488 hydrochloride
Description:
(+)-U-50488 hydrochloride is a selective agonist for κ-opioid receptor . The κ-opioid receptor (KOR) is a type of opioid receptor for opioid peptide dynorphin and controls addiction. Also, KOR plays an important role in stress, anxiety, anhedonia, depression and increased drug-seeking behavior. (+)-U-50488 hydrochloride is a selective KOR agonist . In isolated rat DRG neurons, U-50488 (0.3-40 μM) inhibited voltage-independent Ca2+ channel currents. In HeLa cells that didn’t express KOR, U-50488 (20 μM) blocked Ca2+ channels . In rhesus monkeys, U-50488 exhibited potent antinociceptive activity and produced diuresis . U-50488 enhanced contraction of the rabbit vas deferens induced by electrically with IC50 value of 26.5 nM. In mice, U-50488 impaired motor function with ED50 value of 15.3 mg/kg and reduced spontaneous activity . In adult rats, U-50488 increased the threshold required to maintain self-stimulation responding, a depressive-like effect. While, males were significantly more sensitive than females to the threshold-increasing effects .
CAS:
114528-81-3
Molecular Weight:
405.79
Formula:
C19H27Cl3N2O
Chemical Name:
2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide hydrochloride
Smiles :
Cl.CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)CC1=CC=C(Cl)C(Cl)=C1
InChiKey:
KGMMGVIYOHGOKQ-JAXOOIEVSA-N
InChi :
InChI=1S/C19H26Cl2N2O.ClH/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H/t17-,18-;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(+)-U-50488 hydrochloride is a selective agonist for κ-opioid receptor . The κ-opioid receptor (KOR) is a type of opioid receptor for opioid peptide dynorphin and controls addiction. Also, KOR plays an important role in stress, anxiety, anhedonia, depression and increased drug-seeking behavior. (+)-U-50488 hydrochloride is a selective KOR agonist . In isolated rat DRG neurons, U-50488 (0.3-40 μM) inhibited voltage-independent Ca2+ channel currents.{{Crisaborole} medchemexpress|{Crisaborole} Metabolic Enzyme/Protease|{Crisaborole} Protocol|{Crisaborole} Description|{Crisaborole} supplier|{Crisaborole} Epigenetic Reader Domain} In HeLa cells that didn’t express KOR, U-50488 (20 μM) blocked Ca2+ channels .{{D-Glucose-13C6,d7} web|{D-Glucose-13C6,d7} Bacterial|{D-Glucose-13C6,d7} Epigenetics|{D-Glucose-13C6,d7} Technical Information|{D-Glucose-13C6,d7} Purity|{D-Glucose-13C6,d7} custom synthesis} In rhesus monkeys, U-50488 exhibited potent antinociceptive activity and produced diuresis .PMID:35850484 U-50488 enhanced contraction of the rabbit vas deferens induced by electrically with IC50 value of 26.5 nM. In mice, U-50488 impaired motor function with ED50 value of 15.3 mg/kg and reduced spontaneous activity . In adult rats, U-50488 increased the threshold required to maintain self-stimulation responding, a depressive-like effect. While, males were significantly more sensitive than females to the threshold-increasing effects .|Product information|CAS Number: 114528-81-3|Molecular Weight: 405.79|Formula: C19H27Cl3N2O|Chemical Name: 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide hydrochloride|Smiles: Cl.CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)CC1=CC=C(Cl)C(Cl)=C1|InChiKey: KGMMGVIYOHGOKQ-JAXOOIEVSA-N|InChi: InChI=1S/C19H26Cl2N2O.ClH/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H/t17-,18-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|