Product Name :
BML-284
Description:
BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM.
CAS:
853220-52-7
Molecular Weight:
350.37
Formula:
C19H18N4O3
Chemical Name:
N4-(benzo[d][1, 3]dioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2, 4-diamine
Smiles :
COC1=CC(=CC=C1)C1=CC(NCC2C=C3OCOC3=CC=2)=NC(N)=N1
InChiKey:
FABQUVYDAXWUQP-UHFFFAOYSA-N
InChi :
InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BML-284 hydrochloride is a potent and cell-permeable Wnt signaling activator.{{Bevacizumab} MedChemExpress|{Bevacizumab} VEGFR|{Bevacizumab} Technical Information|{Bevacizumab} In stock|{Bevacizumab} manufacturer|{Bevacizumab} Autophagy} BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM.|Product information|CAS Number: 853220-52-7|Molecular Weight: 350.37|Formula: C19H18N4O3|Chemical Name: N4-(benzo[d][1, 3]dioxol-5-ylmethyl)-6-(3-methoxyphenyl)pyrimidine-2, 4-diamine|Smiles: COC1=CC(=CC=C1)C1=CC(NCC2C=C3OCOC3=CC=2)=NC(N)=N1|InChiKey: FABQUVYDAXWUQP-UHFFFAOYSA-N|InChi: InChI=1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (285.{{Neratinib} medchemexpress|{Neratinib} EGFR|{Neratinib} Purity & Documentation|{Neratinib} Description|{Neratinib} manufacturer|{Neratinib} Cancer} 41 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32712803 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BML-284 (10 µM; 24 hours) induces the expression of β-catenin significantly when compared with the NC group. It also partially reverses the effects induced by pizotifen on E-cadherin and N-cadherin expression in MNK45 and AGS cells compared with the pizotifen-treated group. BML-284 (10 µM; 24 hours) significantly increases the migration and invasion of both MNK45 and AGS cells and partially restores the migratory and invasive abilities of cells inhibited by pizotifen.|In Vivo:|BML-284 hydrochloride (10 ng) combines with Pyrimethanil (4 mg/L) could partially rescue the malformed phenotype and cardiac defects induced by Pyrimethanil in Tg (myl7:EGFP) transgenic embryos at 5.5 hpf are transferred into plates with 20 embryos.|References:|Liu J, et al. A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.Ying Jiang, et al. Pizotifen inhibits the proliferation and invasion of gastric cancer cells. Exp Ther Med. 2020 Feb;19(2):817-824.Yunlong Meng, et al. Exposure to pyrimethanil induces developmental toxicity and cardiotoxicity in zebrafish. Chemosphere. 2020 Sep;255:126889Products are for research use only. Not for human use.|