Product Name :
YK11
Description:
YK11 is a partial agonist of androgen receptor, with osteogenic activity.
CAS:
1370003-76-1
Molecular Weight:
430.53
Formula:
C25H34O6
Chemical Name:
methyl 2-[(1S,3aS,3bR,9bS,11aS)-3a,3b,9b-trihydrogenio-5′-methoxy-5′,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydrospiro[cyclopenta[a]phenanthrene-1,2′-[1,4]dioxolan]-3′-ylidene]acetate
Smiles :
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCC43)[C@@H]1CC[C@@]12OC(C)(O/C/1=C/C(=O)OC)OC
InChiKey:
KCQHQCDHFVGNMK-HWFGOELMSA-N
InChi :
InChI=1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17?,18-,19-,20+,23+,24?,25-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
YK11 is a partial agonist of androgen receptor, with osteogenic activity.Ligelizumab Purity |Product information|CAS Number: 1370003-76-1|Molecular Weight: 430.53|Formula: C25H34O6|Chemical Name: methyl 2-[(1S,3aS,3bR,9bS,11aS)-3a,3b,9b-trihydrogenio-5′-methoxy-5′,11a-dimethyl-7-oxo-2,3,3a,3b,4,5,7,8,9,9a,9b,10,11,11a-tetradecahydrospiro[cyclopenta[a]phenanthrene-1,2′-[1,4]dioxolan]-3′-ylidene]acetate|Smiles: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCC43)[C@@H]1CC[C@@]12OC(C)(O/C/1=C/C(=O)OC)OC|InChiKey: KCQHQCDHFVGNMK-HWFGOELMSA-N|InChi: InChI=1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17?,18-,19-,20+,23+,24?,25-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 64 mg/mL (148.65 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.AEE788 manufacturer |Shelf Life: ≥12 months if stored properly.PMID:33332941 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|YK11 is a partial agonist of androgen receptor, and induces myogenic differentiation of C2C12 Cells at 500 nM via Fst mRNA upregulation by AR. YK11 enhances Myf5 and myogenin mRNA expression, but requires high concentrations (YK11, 100 nM or 500 nM). YK11 (0.5 µM) increases the cell growth of osteoblastic MC3T3-E1 cells, and enhances ALP activity via AR. YK11 also elevates osteoprotegerin mRNA expression (0.5 µM) and dose-dependently increases osteocalcin mRNA expression (0.1-1.0 µM). In addition, YK11 enhances phosphorylation of Akt protein via rapid non-genomic signaling.|References:|Kanno Y, et al. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol Pharm Bull. 2013;36(9):1460-5.Yatsu T, et al. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells. Biol Pharm Bull. 2018;41(3):394-398.Products are for research use only. Not for human use.|