Product Name :
Isoguvacine hydrochloride
Description:
Isoguvacine hydrochloride is a GABA receptor agonist.
CAS:
68547-97-7
Molecular Weight:
163.60
Formula:
C6H10ClNO2
Chemical Name:
1,2,3,6-tetrahydropyridine-4-carboxylic acid hydrochloride
Smiles :
Cl.OC(=O)C1CCNCC=1
InChiKey:
SUWREQRNTXCCBL-UHFFFAOYSA-N
InChi :
InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Isoguvacine hydrochloride is a GABA receptor agonist.|Product information|CAS Number: 68547-97-7|Molecular Weight: 163.60|Formula: C6H10ClNO2|Chemical Name: 1,2,3,6-tetrahydropyridine-4-carboxylic acid hydrochloride|Smiles: Cl.OC(=O)C1CCNCC=1|InChiKey: SUWREQRNTXCCBL-UHFFFAOYSA-N|InChi: InChI=1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (152.81 mM; Need ultrasonic). H2O : ≥ 100 mg/mL (611.25 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Isoguvacine binds to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus.Tamibarotene Biological Activity Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site: that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system; and that recently accumulated isoguvacine is released in a Ca2+-dependent manner and by heteroexchange with external GABA.Polyinosinic-polycytidylic acid Technical Information Isoguvacine at a concentration of 50 μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures.PMID:33305413 Isoguvacine inhibits the low magnesium induced seizure like events dose dependently.|Products are for research use only. Not for human use.|