Se rapidly after various inflammatory conditions, including surgery. Although CRP measurements
Se rapidly after various inflammatory conditions, including surgery. Although CRP measurements are used frequently in the ICU setting, their relation to the development of sepsis, organ failure and mortality is not well known. Objective To correlate plasma CRP levels with prognosis and hospital mortality in the postoperative period. Design A prospective cohort study. Setting A 19-bed medico-surgical ICU in a private hospital. Patients All surgical patients admitted to the ICU over a period of 4 months. Measurements and results In 2005, from September to November, 527 patients were admitted to the ICU. Of them, 435 (82.5 ) patients buy PX-478 pubmed ID:https://www.ncbi.nlm.nih.gov/pubmed/27872238 were admitted for postoperative care, and 219 (50.3 ) were male. The mean age of the whole group was 62.02 ?16 years. Nine (2.06 ) patients died during the postoperative period. Among the patients who died, the mean APACHE and SAPS 2 scores were 17.67 ?9.40 and 52.4 ?18.31, respectively. Among those who survived, the mean APACHE and SAPS 2 scores were 12.11 ?6.35 and 24.66 ?13.03, respectively. Plasma CRP levels during the first 3 days of the ICU stay were not statistically different between patients who survived and those who died. On the fourth day, the plasma CPR level was significantly higher in the group who died, compared with those who survived (28.133 ?4.77 vs 13.849 ?10.4; P = 0.037). Of interest is the fact that, on admission, the APACHE and SAPS 2 scores were higher in the group who survived. The area under the ROC curve for the analysis of plasma CRP levels on the fourth day of the ICU stay was 0.86 (95 CI 0.76?.96) with 100 sensitivity and 75 specificity to predict death in surgical patients. The best cutoff point was 22.7 mg . The mortality in the groupsP77 Low sensitivity of procalcitonin in cerebrospinal fluid in adult patients with bacterial meningitisM Prucha1, P Adam1, M Dostal2, O Sobek1 Na Homolce, Prague, Czech Republic; 2Institute of Experimental Medicine, Prague, Czech Republic Critical Care 2006, 10(Suppl 1):P77 (doi:10.1186/cc4424)1HospitalAim To compare the diagnostic accuracy of procalcitonin (PCT) for early diagnosis and the discrimination of bacterial and viral meningitis.SCritical CareMarch 2006 Vol 10 Suppl26th International Symposium on Intensive Care and Emergency Medicinewith fourth-day PCR <22.7 mg and 22.7 mg was 0 and 25 , respectively (P = 0.011). Conclusion In this cohort, a plasma CPR level higher than 22.7 mg on the fourth day of ICU admission was a good tool to discriminate between patients who died and those who survived. Plasma CRP levels appear to be better at predicting mortality than the APACHE II and SAPS 2 scores at the time of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/25636517 ICU admission.P79 High C-reactive protein and low cholesterol levels are prognostic marker in severe sepsisD Memis, O Gursoy, M Tasdogan, I Kurt, M Ture, B Karamanlioglu Trakya University, Edirne, Turkey Critical Care 2006, 10(Suppl 1):P79 (doi:10.1186/cc4426) Introduction Additional biomarkers in severe sepsis are needed to tackle the challenges of determining prognosis and optimizing selection of high-risk patients for application of therapy. The use of serum cholesterol as a prognostic indicator of infection and multiple organ dysfunction syndrome, and as a biologic marker for resolution of systemic inflammation is less well defined. Proposed explanations for the development of hypocholesterolemia include downregulation of hepatic synthesis, dilutional effects with resuscitation, loss of apoproteins in burns after blister format.