Ypoxia miR-20b miR-199a miR-424 () AKT PU.one (ectopic) Normoxia Hypoxia(ECs) SPRY2 PPAR HIF-1 HIF-1 CUL2 Proliferation, migration Proliferation, migration Verubecestat Inhibitor Reduced HIF-1 Amplified HIF-1 HIF-1 stabilization Sarkar et al. (2010) Sarkar et al. (2010) Cascio et al. (2010) Rane et al. (2009, 2010) Ghosh et al. (2010) MNT GPD1L E-cadherin RAD23B RAD52 PDCD4 Mobile proliferation HIF-1 stabilization Invasion, metastasis DNA damage, mend DNA hurt, repair Anti-apoptotic, proliferation Zhang et al. (2009) Kelly et al. (2011) Position et al. (2008) Crosby et al. (2009a) Crosby et al. (2009a) Cheng et al. (2010) RAD52 CASP8AP2 E2F3 DNA repair Apoptosis Mobile proliferation Crosby et al. (2009a) Kim et al. (2009) Giannakakis et al. (2008) ISCU NDUFA4 SDHD COX10 EFNA3 Mitochondria impairment Mitochondria impairment Mitochondria impairment Mitochondria impairment Mobile migration Favaro et al. (2010), Chan et al. (2009) Puiss ur et al. (2011) Puiss ur et al. (2011) Chen et al. (2010) Fasanaro et al. (2008) Goal mRNA Proposed organic effect
Evaluate ARTICLEMOLECULAR NEUROSCIENCEpublished: 01 November 2011 doi: 10.3389/fnmol.2011.Past cAMP: the regulation of Akt and GSK3 by dopamine receptorsJean-Martin Beaulieu one *, Thomas Del’Guidice 1 , Tatyana D. Sotnikova two , Morgane Lemasson 1 and Raul R. Gainetdinov 2 *1Department of Psychiatry and Neuroscience, UniversitLaval-CRULRG, Qu ec, QC, Canada Section of Neuroscience and Mind Technologies, Istituto Italiano di Tecnologia, Genova, ItalyEdited by: Oksana Kaidanovich-Beilin, Samuel Lunenfeld Investigation Institute, Canada Reviewed by: Cristina Missale, University of Brescia, Italy Fabio Fumagalli, College of Milan, Italy Denis Joseph David, UniversitParis-Sud, France *Correspondence: Jean-Martin Beaulieu, Office of Psychiatry and Neuroscience, UniversitLaval-CRULRG, 2601 Chemin de la Canardi e, Suite F-6500, Beauport, Qu ec, QC, Canada G1J 2G3. e-mail: martin.beaulieu@crulrg. ulaval.ca; Raul R. Gainetdinov , Office of Neuroscience and Brain Systems, Italian Institute of Technology, Through Morego thirty, Genova 16167 Italy. , e-mail: [email protected] dopamine receptors are chosen targets for numerous pharmacological compounds produced for your therapy of varied neuropsychiatric diseases. Recent discovery that D2 dopamine receptors, in addition to cAMP pathways, can have interaction also in Akt/GSK3 signaling cascade delivered a 1009817-63-3 Description completely new framework to know intracellular signaling mechanisms associated with dopamine-related behaviors and pathologies. Right here we evaluation a new progress in being familiar with the position of Akt, GSK3, and associated signaling molecules in dopamine receptor signaling and functions. 82321-04-8 site Notably, we concentrate around the molecular mechanisms included, interacting companions, role of those signaling situations during the action of antipsychotics, psychostimulants, and antidepressants at the same time as involvement in pathophysiology of schizophrenia, bipolar ailment, and Parkinson’s condition. Even further knowing with the role of Akt/GSK3 signaling in dopamine receptor features could offer novel targets for pharmacological interventions in dopamine-related issues.Key phrases: glycogen synthase kinase three,Akt, protein kinase B, dopamine, catecholamines, arrestin, G protein coupled receptor, receptor tyrosine kinaseINTRODUCTION Dopamine is really a catecholamine neurotransmitter involved with the regulation of several features from the CNS and periphery, which include locomotion, cognition, psychological behaviors, and endocr.