Product Name :
Omarigliptin (MK-3102)
CAS No.:
1226781-44-7
Purity :
> 99%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
C[S](=O)(=O)[N]1C=C2CN(CC2=N1)C3COC(C(N)C3)C4=C(F)C=CC(=C4)F
Product Description :
Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.6 nM, Ki = 0.8 nM). It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5).
Formula:
C17H20F2N4O3S
Molecular Weight :
398.43
Synonyms:
Additional Information:
|CAS No. 1226781-44-7 ; |Formula C17H20F2N4O3S ; |Molecular Weight 398.43 ; |SMILES C[S](=O)(=O)[N]1C=C2CN(CC2=N1)C3COC(C(N)C3)C4=C(F)C=CC(=C4)F ; |Product Description Omarigliptin (MK-3102) is a competitive, reversible inhibitor of DPP-4 (IC50 = 1.{{Cabozantinib} MedChemExpress|{Cabozantinib} Protein Tyrosine Kinase/RTK|{Cabozantinib} Biological Activity|{Cabozantinib} References|{Cabozantinib} supplier|{Cabozantinib} Autophagy} 6 nM, Ki = 0.{{CCMI} web|{CCMI} Membrane Transporter/Ion Channel|{CCMI} Purity & Documentation|{CCMI} In Vitro|{CCMI} manufacturer|{CCMI} Cancer} 8 nM).PMID:23812309 It is highly selective over all proteases tested (IC50 > 67 μM), including QPP, FAP, PEP, DPP8, and DPP9 and has weak ion channel activity (IC50 > 30 μM at IKr, Caγ1.2, and Naγ1.5). ; |Purity > 99% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO