Product Name :
Darapladib
Description:
Darapladib, also known as SB-480848, is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM, which is in Phase 3 trials. Recent studies showed that risk of major coronary events not reduced by darapladib therapy. In patients with stable coronary heart disease, darapladib did not significantly reduce the risk of the primary composite end point of cardiovascular death, myocardial infarction, or stroke.
CAS:
356057-34-6
Molecular Weight:
666.77
Formula:
C36H38F4N4O2S
Chemical Name:
N-[2-(diethylamino)ethyl]-2-(2-{[(4-fluorophenyl)methyl]sulfanyl}-4-oxo-1H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-1-yl)-N-{[4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl]methyl}acetamide
Smiles :
CCN(CCN(CC1C=CC(=CC=1)C1C=CC(=CC=1)C(F)(F)F)C(=O)CN1C(=NC(=O)C2CCCC1=2)SCC1=CC=C(F)C=C1)CC
InChiKey:
WDPFJWLDPVQCAJ-UHFFFAOYSA-N
InChi :
InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Darapladib, also known as SB-480848, is a reversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with IC50 of 0.25 nM, which is in Phase 3 trials. Recent studies showed that risk of major coronary events not reduced by darapladib therapy. In patients with stable coronary heart disease, darapladib did not significantly reduce the risk of the primary composite end point of cardiovascular death, myocardial infarction, or stroke.|Product information|CAS Number: 356057-34-6|Molecular Weight: 666.77|Formula: C36H38F4N4O2S|Chemical Name: N-[2-(diethylamino)ethyl]-2-(2-{[(4-fluorophenyl)methyl]sulfanyl}-4-oxo-1H,4H,5H,6H,7H-cyclopenta[d]pyrimidin-1-yl)-N-{[4′-(trifluoromethyl)-[1,1′-biphenyl]-4-yl]methyl}acetamide|Smiles: CCN(CCN(CC1C=CC(=CC=1)C1C=CC(=CC=1)C(F)(F)F)C(=O)CN1C(=NC(=O)C2CCCC1=2)SCC1=CC=C(F)C=C1)CC|InChiKey: WDPFJWLDPVQCAJ-UHFFFAOYSA-N|InChi: InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Protamine} web|{Protamine} Metabolic Enzyme/Protease|{Protamine} Biological Activity|{Protamine} References|{Protamine} supplier|{Protamine} Cancer} |Shelf Life: ≥360 days if stored properly.{{Siltuximab} site|{Siltuximab} Interleukin Related|{Siltuximab} Purity & Documentation|{Siltuximab} Description|{Siltuximab} custom synthesis|{Siltuximab} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:25818744 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|