Product Name :
Aurora A Inhibitor I
Description:
Aurora A Inhibitor I is a selective inhibitor of Aurora kinase A.
CAS:
1158838-45-9
Molecular Weight:
588.07
Formula:
C31H31ClFN7O2
Chemical Name:
N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide
Smiles :
CCN1CCN(CC1)C(=O)CC1C=CC(=CC=1)NC1=NC(NC2C=CC(=CC=2)C(=O)NC2=CC=CC=C2Cl)=C(F)C=N1
InChiKey:
AKSIZPIFQAYJGF-UHFFFAOYSA-N
InChi :
InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Aurora A Inhibitor I is a selective inhibitor of Aurora kinase A.|Product information|CAS Number: 1158838-45-9|Molecular Weight: 588.07|Formula: C31H31ClFN7O2|Synonym:|TC-S 7010|TCS7010|TC S 7010|Aurora A Inhibitor I|Chemical Name: N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide|Smiles: CCN1CCN(CC1)C(=O)CC1C=CC(=CC=1)NC1=NC(NC2C=CC(=CC=2)C(=O)NC2=CC=CC=C2Cl)=C(F)C=N1|InChiKey: AKSIZPIFQAYJGF-UHFFFAOYSA-N|InChi: InChI=1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)|Technical Data|Appearance: Solid Power.{{Oleic acid} medchemexpress|{Oleic acid} Apoptosis|{Oleic acid} Purity & Documentation|{Oleic acid} Data Sheet|{Oleic acid} custom synthesis|{Oleic acid} Autophagy} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Zinc Pyrithione} MedChemExpress|{Zinc Pyrithione} Apoptosis|{Zinc Pyrithione} Technical Information|{Zinc Pyrithione} References|{Zinc Pyrithione} supplier|{Zinc Pyrithione} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:23558135 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Aurora A Inhibitor I is exceptionally selective Aurora A inhibitors. Aurora A Inhibitor I is an useful tool compounds for investigating the cellular role of Aurora A kinases without the complication of also inhibiting Aurora B.|References:|Lee DH, Kim CG, Lim Y, Shin SY. Aurora kinase A inhibitor Aurora A Inhibitor Idemonstrates pro-apoptotic effect through the unfolded protein response pathway in HCT116 colon cancer cells. Oncol Lett. 2017 Dec;14(6):6571-6577. doi: 10.3892/ol.2017.7023. Epub 2017 Sep 22. PubMed PMID: 29163689; PubMed Central PMCID: PMC5686436.Products are for research use only. Not for human use.|