Product Name :
PROTAC Sirt2 Degrader-1
Description:
Sirt2-PROTAC-1 is a SirReal based PROTAC, inducing isotype-selective Sirt2 degradation. PROTAC Sirt2 Degrader-1 is composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).
CAS:
2098487-75-1
Molecular Weight:
852.94
Formula:
C40H40N10O8S2
Chemical Name:
N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide
Smiles :
CC1C=C(C)N=C(N=1)SCC(=O)NC1=NC=C(CC2=CC(=CC=C2)OCC2=CN(CCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)S1
InChiKey:
GRYRXFYWVDWPQY-UHFFFAOYSA-N
InChi :
InChI=1S/C40H40N10O8S2/c1-23-15-24(2)44-40(43-23)59-22-34(53)46-39-42-18-28(60-39)17-25-7-5-8-27(16-25)57-20-26-19-49(48-47-26)14-4-3-13-41-33(52)21-58-31-10-6-9-29-35(31)38(56)50(37(29)55)30-11-12-32(51)45-36(30)54/h5-10,15-16,18-19,30H,3-4,11-14,17,20-22H2,1-2H3,(H,41,52)(H,42,46,53)(H,45,51,54)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Sirt2-PROTAC-1 is a SirReal based PROTAC, inducing isotype-selective Sirt2 degradation. PROTAC Sirt2 Degrader-1 is composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s>100 μM).|Product information|CAS Number: 2098487-75-1|Molecular Weight: 852.94|Formula: C40H40N10O8S2|Chemical Name: N-{4-[4-({3-[(2-{2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]acetamido}-1,3-thiazol-5-yl)methyl]phenoxy}methyl)-1H-1,2,3-triazol-1-yl]butyl}-2-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}acetamide|Smiles: CC1C=C(C)N=C(N=1)SCC(=O)NC1=NC=C(CC2=CC(=CC=C2)OCC2=CN(CCCCNC(=O)COC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)N=N2)S1|InChiKey: GRYRXFYWVDWPQY-UHFFFAOYSA-N|InChi: InChI=1S/C40H40N10O8S2/c1-23-15-24(2)44-40(43-23)59-22-34(53)46-39-42-18-28(60-39)17-25-7-5-8-27(16-25)57-20-26-19-49(48-47-26)14-4-3-13-41-33(52)21-58-31-10-6-9-29-35(31)38(56)50(37(29)55)30-11-12-32(51)45-36(30)54/h5-10,15-16,18-19,30H,3-4,11-14,17,20-22H2,1-2H3,(H,41,52)(H,42,46,53)(H,45,51,54)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Rucaparib} MedChemExpress|{Rucaparib} PARP|{Rucaparib} Protocol|{Rucaparib} References|{Rucaparib} custom synthesis|{Rucaparib} Epigenetic Reader Domain} |Shelf Life: ≥12 months if stored properly.{{Anti-B7-H4/VTCN1 Antibody} web|{Anti-B7-H4/VTCN1 Antibody} Epigenetics|{Anti-B7-H4/VTCN1 Antibody} Purity & Documentation|{Anti-B7-H4/VTCN1 Antibody} In Vivo|{Anti-B7-H4/VTCN1 Antibody} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23937941 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|PROTAC Sirt2 Degrader-1 (Compound 12; 10 µM, 1-6 hours) induces Sirt2 degradation in HeLa cells|Products are for research use only. Not for human use.|