Product Name :
PTP1B/AKR1B1-IN-1
CAS No.:
Purity :
Shipping:
Room temperature in the continental U.S. Other areas may vary.
Storage :
Please store the product under the recommended conditions in the Certificate of Analysis.
SMILES:
O=C(CN1C(/C(SC1=S)=C/C2=CC=CC(OCCCCC3=CC=CC=C3)=C2)=O)O
Product Description :
PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.06 μM and 4.3 μM, respectively. PTP1B/AKR1B1-IN-1 also inhibits TC-PTP with an IC50 value of 9 μM. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus (T2DM) to control blood glucose levels.
Formula:
C22H21NO4S2
Molecular Weight :
427.{{Desmosterol} web|{Desmosterol} Endogenous Metabolite|{Desmosterol} Protocol|{Desmosterol} In stock|{Desmosterol} custom synthesis|{Desmosterol} Autophagy} 54
Synonyms:
Additional Information:
|Formula C22H21NO4S2 ; |Molecular Weight 427.{{NLRP1 Protein, Human} site|{NLRP1 Protein, Human} Technical Information|{NLRP1 Protein, Human} Formula|{NLRP1 Protein, Human} manufacturer|{NLRP1 Protein, Human} Autophagy} 54 ; |SMILES O=C(CN1C(/C(SC1=S)=C/C2=CC=CC(OCCCCC3=CC=CC=C3)=C2)=O)O ; |Target Phosphatase, Aldose Reductase ; |Product Description PTP1B/AKR1B1-IN-1 is a dual inhibitor of protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AKR1B1), with IC50s of 0.PMID:24268253 06 μM and 4.3 μM, respectively. PTP1B/AKR1B1-IN-1 also inhibits TC-PTP with an IC50 value of 9 μM. PTP1B/AKR1B1-IN-1 serves as an insulin-mimetic agent in murine myoblasts, and reduces AKR1B1-dependent sorbitol accumulation. PTP1B/AKR1B1-IN-1 inhibits development of type 2 diabetes mellitus (T2DM) to control blood glucose levels. ; |Shipping Room temperature in the continental U.S. Other areas may vary. ; |Storage Please store the product under the recommended conditions in the Certificate of Analysis.