Product Name :
Regorafenib Monohydrate
CAS No.:
1019206-88-2
Purity :
> 99%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(=C2)F
Product Description :
Regorafenib is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respectively.
Formula:
C21H17ClF4N4O4
Molecular Weight :
500.83
Synonyms:
Additional Information:
|CAS No. 1019206-88-2 ; |Formula C21H17ClF4N4O4 ; |Molecular Weight 500.83 ; |SMILES O.CNC(=O)C1=NC=CC(=C1)OC2=CC=C(NC(=O)NC3=CC=C(Cl)C(=C3)C(F)(F)F)C(=C2)F ; |Product Description Regorafenib is a novel oral multikinase inhibitor with IC50 values of 13, 4.{{TCEP} site|{TCEP} Biological Activity|{TCEP} In Vitro|{TCEP} custom synthesis|{TCEP} Autophagy} 2, 46, 22, 7, 1.{{Nifedipine} MedChemExpress|{Nifedipine} Neuronal Signaling|{Nifedipine} Technical Information|{Nifedipine} In Vivo|{Nifedipine} custom synthesis|{Nifedipine} Cancer} 5, 2.PMID:23554582 5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-β, KIT, RET, RAF-1, B-RAF and B-RAF(V600E) respectively. ; |Purity > 99% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO