Product Name :
AMG-1694
CAS No.:
1361217-07-3
Purity :
> 98%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
Product Description :
AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity. AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.{{PA452} medchemexpress|{PA452} Vitamin D Related/Nuclear Receptor|{PA452} Protocol|{PA452} Data Sheet|{PA452} custom synthesis|{PA452} Cancer} AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals.
Formula:
C23H30F3N3O4S2
Molecular Weight :
533.63
Synonyms:
Additional Information:
|CAS No. 1361217-07-3 ; |Formula C23H30F3N3O4S2 ; |Molecular Weight 533.63 ; |Product Description AMG-1694 is a potent glucokinase–glucokinase regulatory protein (GK-GKRP) disruptors and promotes the dissociation of the GK-GKRP complex with an IC50 of 7 nM, indirectly increasing GK enzymatic activity.{{Fluphenazine} site|{Fluphenazine} Membrane Transporter/Ion Channel|{Fluphenazine} Purity & Documentation|{Fluphenazine} In Vitro|{Fluphenazine} supplier|{Fluphenazine} Epigenetic Reader Domain} AMG-1694 potently reverses the inhibitory effect of GKRP on GK activity and promotes GK translocation.PMID:26644518 AMG-1694 normalizes blood glucose levels in several rodent models of diabetes and lowes blood glucose restricted to diabetic and not normoglycaemic animals. ; |Format Solid ; |Purity > 98% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO