Product Name :
GNF2133
CAS No.:
2561414-56-8
Purity :
> 98%
Shipping:
Shipped on dry ice.
Storage :
Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month
SMILES:
Product Description :
GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes.
Formula:
C24H30N6O2
Molecular Weight :
434.{{862111-32-8} web|{862111-32-8} Protocol|{862111-32-8} Data Sheet|{862111-32-8} custom synthesis} 53
Synonyms:
Additional Information:
|CAS No.{{83366-66-9} MedChemExpress|{83366-66-9} Purity & Documentation|{83366-66-9} Data Sheet|{83366-66-9} custom synthesis} 2561414-56-8 ; |Formula C24H30N6O2 ; |Molecular Weight 434.PMID:29083635 53 ; |Target DYRK1A ; |Product Description GNF2133 is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3β, respectively. GNF2133 shows good proliferation potency and efficacy on rat and human primary β-cell. GNF2133 significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 has the potential for the research of type 1 diabetes. ; |Format Solid ; |Purity > 98% ; |Shipping Shipped on dry ice. ; |Storage Powder: -20 °C, 3 years; 4 °C, 2 yearsIn solvent: -80 °C, 6 months; -20 °C, 1 month ; |Solubility Overview Soluble in DMSO