Product Name :
GSK-3β inhibitor 1
Description:
GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM.
CAS:
187325-53-7
Molecular Weight:
222.24
Formula:
C14H10N2O
Chemical Name:
(Z)-3-(pyridin-2-ylmethylene)indolin-2-one
Smiles :
O=C1NC2=CC=CC=C2/C/1=C/C1=CC=CC=N1
InChiKey:
YKQONSWBHGBDSB-XFXZXTDPSA-N
InChi :
InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM.|Product information|CAS Number: 187325-53-7|Molecular Weight: 222.24|Formula: C14H10N2O|Chemical Name: (Z)-3-(pyridin-2-ylmethylene)indolin-2-one|Smiles: O=C1NC2=CC=CC=C2/C/1=C/C1=CC=CC=N1|InChiKey: YKQONSWBHGBDSB-XFXZXTDPSA-N|InChi: InChI=1S/C14H10N2O/c17-14-12(9-10-5-3-4-8-15-10)11-6-1-2-7-13(11)16-14/h1-9H,(H,16,17)/b12-9-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 33.{{Norfluoxetine} medchemexpress|{Norfluoxetine} Membrane Transporter/Ion Channel|{Norfluoxetine} TGF-beta/Smad|{Norfluoxetine} Biological Activity|{Norfluoxetine} In Vitro|{Norfluoxetine} custom synthesis} 33 mg/mL (149.{{L-Asparaginase} MedChemExpress|{L-Asparaginase} DNA/RNA Synthesis|{L-Asparaginase} Biological Activity|{L-Asparaginase} Formula|{L-Asparaginase} custom synthesis|{L-Asparaginase} Cancer} 97 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32767801 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817.Products are for research use only. Not for human use.|