Product Name :
Progranulin (human), (recombinant)
Sequence:
Purity:
≥95% (SDS-PAGE)
Molecular Weight:
~90-95kDa
Solubility :
Appearance:
Use/Stability :
Working aliquots are stable for up to 3 months when stored at -20°C.
Description:
Progranulin (PGRN) has been shown to be a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signalling cascades that control cell cycle progression and cell motility. PGRN has also been linked to tumorigenesis.{{143653-53-6} web|{143653-53-6} Technical Information|{143653-53-6} Data Sheet|{143653-53-6} custom synthesis} The function of PGRN in the central nervous system (CNS) is also of interest, because mutations in the PGRN gene have been identified in cases of frontotemporal degeneration (FTD).{{1445879-21-9} site|{1445879-21-9} Purity & Documentation|{1445879-21-9} Formula|{1445879-21-9} custom synthesis}
CAS :
Solubility:
Formula:
Additional Information :
| Activity Measured by its ability to enhance neurite outgrowth of E16E18 rat embryonic cortical neurons.PMID:31474151 rhProgranulin, immobilized at 1040 μg/ml on a nitrocellulose coated plate, is able to significantly enhance neurite outgrowth. | Alternative Name Proepithelin, PEPI, PC cell-derived growth factor | Endotoxin Content | Formulation Lyophilized from a 0.2 μm filtered solution in PBS. | MW ~90-95kDa | Purity ≥95% (SDS-PAGE) | Reconstitution Reconstitute at 200μg/ml in sterile PBS. | Source Produced in mouse myeloma cell line NS0. Human progranulin (aa 18-593) is fused at the C-terminus to a 6-His tag. | UniProt ID P28799