Pproved the fil manuscript. Acknowledgements This investigation was supported by Wellcome Trust Grant BZ and BBSRC grant BBE. Author information School of Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS JT, UK. Institute of Pharmaceutical Science, King’s College London, Stamford Street, London SE NH, UK. Received: December Accepted: April Published: April References. van Nimwegen E: Scaling laws within the functiol content material of genomes. Trendenet, :. Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA: Structure and evolution of transcriptiol regulatory networks. Curr Opin Struc Biol, :. MacNeil LT, Walhout AJM: Gene regulatory networks and also the function of robustness and stochasticity inside the handle of gene expression. Genome Res, :. ReeceHoyes JS, Deplancke B, Shingles J, Grove CA, Hope IA, Walhout AJM: A compendium of Caenorhabditis Calcipotriol Impurity C elegans regulatory transcription elements: a resource for mapping transcription regulatory networks. Genome Biol, :R. ReeceHoyes JS, Diallo A, GDC-0853 price Lajoie B, Kent A, Shrestha S, Kadreppa S, Pesy C, Dekker J, Myers CL, Walhout AJM: Enhanced yeast onehybrid assays for highthroughput genecentered regulatory network mapping. t Approaches, :. Hughes AL, Friedman R: Altertive splicing, gene duplication and connectivity in the genetic interaction network of the nematode worm Caenorhabditis elegans. Genetica, :. Kim E, Magen A, Ast G: Diverse levels of altertive splicing amongst eukaryotes. Nucleic Acids Res, :. Ramani AK, Calarco JA, Pan Q, Mavandadi S, Wang Y, Nelson AC, Lee LJ, Morris Q, Blencowe BJ, Zhen M, Fraser AG: Genomewide alysis of altertive splicing in Caenorhabditis elegans. Genome Res, :. Kuroyagi H, Ohno G, Sakane H, Maruoka H, Hagiwara M: Visualization and genetic alysis of altertive splicing regulation in vivo applying fluorescence reporters in transgenic Caenorhabditis elegans. t Protoc, :. Dolphin CT, Hope IA: Caenorhabditis elegans reporter fusion geneenerated by seamless modification of huge genomic D clones. Nucleic Acids Res, :e. Bamps S, Hope IA: Largescale gene expression pattern alysis, in situ, in Caenorhabditis elegans. Brief Funct Genomic Proteomic, :. Tursun B, Cochella L, Carrera I, Hobert O: A toolkit and robust pipeline for the generation of fosmidbased reporter genes in C. elegans. 1, :e. Choi J, Newman AP: A twopromoter system of gene expression in C. elegans. Dev Biol, :. Mango SE: Stop generating nonSense: the C. elegans smg genes. Trendenet, :. Bamps S, Wirtz J, Hope IA: Distinct mechanisms for delimiting expression of four Caenorhabditis elegans transcription element genes encoding activators or repressors. Mol Genet Genomics, : Dupuy D, Li QR, Deplancke B, Boxem M, Hao T, Lamesch P, Sequerra R, Bosak S, DoucetteStamm L, Hope IA, Hill DE, Walhout AJM, Vidal M: A initial version with the Caenorhabditis elegans promoterome. Genome Res, :. ReeceHoyes JS, Shingles J, Dupuy D, Grove CA, Walhout AJ, Vidal M, Hope IA: 
Insight into transcription element gene duplication from Caenorhabditis elegans Promoteromedriven expression patterns. BMC Genomics, :. Reboul J, Vaglio P, Rual JF, Lamesch P, Martinez M, Armstrong CM, Li SM, Jacotot L, Bertin PubMed ID:http://jpet.aspetjournals.org/content/103/3/249 N, Janky R, Moore T, Hudson JR, Hartley JL, Brasch MA, Vandenhaute J, Boulton S, EndresA, Jen S, Chevet E, Papasotiropoulos V, Tolias PP, Ptacek J, Snyder M, Huang R, Chance MR, Lee HM, DoucetteStamm L, Hill DE, Vidal M: C. elegans ORFeome version.: experimental verification on the genome annotation and resource for proteomescale protein expression. t.Pproved the fil manuscript. Acknowledgements This analysis was supported by Wellcome Trust Grant BZ and BBSRC grant BBE. Author details School of Biology, Faculty of Biological Sciences, The University of Leeds, Leeds LS JT, UK. Institute of Pharmaceutical Science, King’s College London, Stamford Street, London SE NH, UK. Received: December Accepted: April Published: April References. van Nimwegen E: Scaling laws in the functiol content material of genomes. Trendenet, :. Babu MM, Luscombe NM, Aravind L, Gerstein M, Teichmann SA: Structure and evolution of transcriptiol regulatory networks. Curr Opin Struc Biol, :. MacNeil LT, Walhout AJM: Gene regulatory networks along with the part of robustness and stochasticity in the manage of gene expression. Genome Res, :. ReeceHoyes JS, Deplancke B, Shingles J, Grove CA, Hope IA, Walhout AJM: A compendium of Caenorhabditis elegans regulatory transcription components: a resource for mapping transcription regulatory networks. Genome Biol, :R. ReeceHoyes JS, Diallo A, Lajoie B, Kent A, Shrestha S, Kadreppa S, Pesy C, Dekker J, Myers CL, Walhout AJM: Enhanced yeast onehybrid assays for highthroughput genecentered regulatory network mapping. t Solutions, :. Hughes AL, Friedman R: Altertive splicing, gene duplication and connectivity inside the genetic interaction network on the nematode worm Caenorhabditis elegans. Genetica, :. Kim E, Magen A, Ast G: Distinctive levels of altertive splicing among eukaryotes. Nucleic Acids Res, :. Ramani AK, Calarco JA, Pan Q, Mavandadi S, Wang Y, Nelson AC, Lee LJ, Morris Q, Blencowe BJ, Zhen M, Fraser AG: Genomewide alysis of altertive splicing in Caenorhabditis elegans. Genome Res, :. Kuroyagi H, Ohno G, Sakane H, Maruoka H, Hagiwara M: Visualization and genetic alysis of altertive splicing regulation in vivo making use of fluorescence reporters in transgenic Caenorhabditis elegans. t Protoc, :. Dolphin CT, Hope IA: Caenorhabditis elegans reporter fusion geneenerated by seamless modification of significant genomic D clones. Nucleic Acids Res, :e. Bamps S, Hope IA: Largescale gene expression pattern alysis, in situ, in Caenorhabditis elegans. Brief Funct Genomic Proteomic, :. Tursun B, Cochella L, Carrera I, Hobert O: A toolkit and robust pipeline 
for the generation of fosmidbased reporter genes in C. elegans. 1, :e. Choi J, Newman AP: A twopromoter technique of gene expression in C. elegans. Dev Biol, :. Mango SE: Stop generating nonSense: the C. elegans smg genes. Trendenet, :. Bamps S, Wirtz J, Hope IA: Distinct mechanisms for delimiting expression of four Caenorhabditis elegans transcription element genes encoding activators or repressors. Mol Genet Genomics, : Dupuy D, Li QR, Deplancke B, Boxem M, Hao T, Lamesch P, Sequerra R, Bosak S, DoucetteStamm L, Hope IA, Hill DE, Walhout AJM, Vidal M: A first version on the Caenorhabditis elegans promoterome. Genome Res, :. ReeceHoyes JS, Shingles J, Dupuy D, Grove CA, Walhout AJ, Vidal M, Hope IA: Insight into transcription issue gene duplication from Caenorhabditis elegans Promoteromedriven expression patterns. BMC Genomics, :. Reboul J, Vaglio P, Rual JF, Lamesch P, Martinez M, Armstrong CM, Li SM, Jacotot L, Bertin PubMed ID:http://jpet.aspetjournals.org/content/103/3/249 N, Janky R, Moore T, Hudson JR, Hartley JL, Brasch MA, Vandenhaute J, Boulton S, EndresA, Jen S, Chevet E, Papasotiropoulos V, Tolias PP, Ptacek J, Snyder M, Huang R, Likelihood MR, Lee HM, DoucetteStamm L, Hill DE, Vidal M: C. elegans ORFeome version.: experimental verification of the genome annotation and resource for proteomescale protein expression. t.