Gies, community leaders, providers, and PLWHA identified some ways in which HIV stigma could be addressed and combated should HIV clinical trials be implemented locally in rural communities. The following examples were elicited from a question asking about views of a mobile van as a mechanism to conduct HIV clinical trials locally: PLWHA: Testing. I think it [mobile van] should do blood pressure. I think it should do a lot of other things because then that way people won’t stay focused just on HIV…if they do other testing it would make it justified for me to walk up to the van and get some pills from you or, or get a box from you and say I went and got tested…And it wouldn’t mean so much exposure… Providers: Just a fear of people finding out that van’s parked there and what it’s here for, `cause it won’t take long. That’s why I said if you do it with otherN C Med J. Author manuscript; available in PMC 2011 February 11.Sengupta et al.Pageservices…You could bundle the services…Like medical…or wellness screening… You’ve got to say something different than say, `hey I’m the HIV bus.’ Community leaders: The community as a whole doesn’t even know what the true purpose of that van is…You really have to camouflage…It has an ulterior motive and you also have to have an underground mode of communications for the people that you want to get in, to go to it…so there’s no stigma attached.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptDiscussionAlthough the multifaceted concept of HIV stigma is not new in the field of HIV/AIDS, we never expected the problem of HIV stigma to still be so prominent in US communities in the 21st century. Using Thonzonium (bromide) biological activity existing theoretical constructs, we explored the types of HIV stigma evident in rural, minority communities of North Carolina, but this is the first study to use the guided framework to develop a conceptual model exploring HIV stigma and its potential impact on HIV clinical trial AlvocidibMedChemExpress HMR-1275 implementation in rural communities. In general, the guided theoretical framework was useful in classifying HIV stigma themes under the constructs of perceived stigma, experienced stigma, vicarious stigma, and felt normative stigma. It was not clear, however, if some of the HIV stigma themes–specifically those from PLWHA interviews–could have been classified under internalized stigma given that their expression in the textual data did not necessarily reflect PLWHA self-blame or their agreement with the negative attitudes the community may have had about them. We did not consider internalized stigma to be a problem a priori and, for this reason, did not ask PLWHA with follow-up probes if they agreed or believed in some of the stigmatizing views reported in their communities. This could be considered a study limitation given that it would be important to understand the extent of internalized stigma in the community for the purposes of targeted stigma reduction interventions at the PLWHA level. The relationships among perceived stigma, experienced stigma, vicarious stigma, and felt normative stigma were significant. In our conceptual model, we were hypothesizing that felt normative stigma was more of a consequence of the other HIV constructs (perceived stigma, experienced stigma, vicarious stigma), thus creating possible scenarios where PLWHA are passing as persons who are not infected or have some other non-stigmatized disease (e.g., if PLWHA have significant weight loss, they tell their commu.Gies, community leaders, providers, and PLWHA identified some ways in which HIV stigma could be addressed and combated should HIV clinical trials be implemented locally in rural communities. The following examples were elicited from a question asking about views of a mobile van as a mechanism to conduct HIV clinical trials locally: PLWHA: Testing. I think it [mobile van] should do blood pressure. I think it should do a lot of other things because then that way people won’t stay focused just on HIV…if they do other testing it would make it justified for me to walk up to the van and get some pills from you or, or get a box from you and say I went and got tested…And it wouldn’t mean so much exposure… Providers: Just a fear of people finding out that van’s parked there and what it’s here for, `cause it won’t take long. That’s why I said if you do it with otherN C Med J. Author manuscript; available in PMC 2011 February 11.Sengupta et al.Pageservices…You could bundle the services…Like medical…or wellness screening… You’ve got to say something different than say, `hey I’m the HIV bus.’ Community leaders: The community as a whole doesn’t even know what the true purpose of that van is…You really have to camouflage…It has an ulterior motive and you also have to have an underground mode of communications for the people that you want to get in, to go to it…so there’s no stigma attached.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptDiscussionAlthough the multifaceted concept of HIV stigma is not new in the field of HIV/AIDS, we never expected the problem of HIV stigma to still be so prominent in US communities in the 21st century. Using existing theoretical constructs, we explored the types of HIV stigma evident in rural, minority communities of North Carolina, but this is the first study to use the guided framework to develop a conceptual model exploring HIV stigma and its potential impact on HIV clinical trial implementation in rural communities. In general, the guided theoretical framework was useful in classifying HIV stigma themes under the constructs of perceived stigma, experienced stigma, vicarious stigma, and felt normative stigma. It was not clear, however, if some of the HIV stigma themes–specifically those from PLWHA interviews–could have been classified under internalized stigma given that their expression in the textual data did not necessarily reflect PLWHA self-blame or their agreement with the negative attitudes the community may have had about them. We did not consider internalized stigma to be a problem a priori and, for this reason, did not ask PLWHA with follow-up probes if they agreed or believed in some of the stigmatizing views reported in their communities. This could be considered a study limitation given that it would be important to understand the extent of internalized stigma in the community for the purposes of targeted stigma reduction interventions at the PLWHA level. The relationships among perceived stigma, experienced stigma, vicarious stigma, and felt normative stigma were significant. In our conceptual model, we were hypothesizing that felt normative stigma was more of a consequence of the other HIV constructs (perceived stigma, experienced stigma, vicarious stigma), thus creating possible scenarios where PLWHA are passing as persons who are not infected or have some other non-stigmatized disease (e.g., if PLWHA have significant weight loss, they tell their commu.